9V0X
Cryo-EM structure of Gq-coupled PrRPR in complex with GUB08248
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(324) subunit alpha | polymer | 361 | 41708.4 | 1 | Homo sapiens | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) | Homo sapiens (human) | |
| 3 | C (E) | scFv16 | polymer | 247 | 26277.3 | 1 | Homo sapiens | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 5 | E (L) | GUB08248 | polymer | 11 | 1234.5 | 1 | Homo sapiens | ||
| 6 | F (R) | Prolactin-releasing peptide receptor | polymer | 370 | 41163.5 | 1 | UniProt (P49683) | Homo sapiens (human) | PrRP receptor,PrRPR,G-protein coupled receptor 10,hGR3 |
| 7 | G (L) | KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] | non-polymer | 717.9 | 1 | Chemie (KUT) |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Gly 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Ser 358 | - | expression tag |
| Ser 359 | - | expression tag |
| Gly 360 | - | expression tag |
| Val 361 | - | expression tag |
| Ser 362 | - | expression tag |
| Gly 363 | - | expression tag |
| Trp 364 | - | expression tag |
| Arg 365 | - | expression tag |
| Leu 366 | - | expression tag |
| Phe 367 | - | expression tag |
| Lys 368 | - | expression tag |
| Lys 369 | - | expression tag |
| Ile 370 | - | expression tag |
| Ser 371 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158340.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 717.9 | |
| All* | Total formula weight | 159058.5 |
