9UZT

Crystal structure of human PTPN2 with inhibitor K-38

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Tyrosine-protein phosphatase non-receptor type 2	polymer	300	34932.6	1	UniProt (P17706) Pfam (PF00102)	Homo sapiens (human)	T-cell protein-tyrosine phosphatase,TCPTP
2	B (B)	~{N}-cycloheptyl-4-[3-fluoranyl-5-oxidanyl-4-[1,1,4-tris(oxidanylidene)-1,2,5-thiadiazolidin-2-yl]phenyl]-1~{H}-imidazole-2-carboxamide	non-polymer		451.5	1	Chemie (A1EQR)
3	C (B)	water	water		18.0	152	Chemie (HOH)

Sequence modifications

B: 5 - 296 (UniProt: P17706)

PDB	External Database	Details
Pro -3	-	expression tag
Leu -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Pro 1	-	expression tag
Trp 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34932.6
Non-Polymers*	Number of molecules	1
	Total formula weight	451.5
All*	Total formula weight	35384.1

*Water molecules are not included.