9UZ5

Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) complexed with 5-methyl-L-Trp

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose/maltodextrin-binding periplasmic protein,Indoleamine 2,3-dioxygenase 2	polymer	782	86825.9	1	UniProt (P0AEY0) UniProt (Q6ZQW0)	Homo sapiens (human)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,IDO-2,Indoleamine 2,3-dioxygenase-like protein 1,Indoleamine-pyrrole 2
2	B (B)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)
3	C, D, E, F, G (A)	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
4	H (A)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
5	I (A)	CYANIDE ION	non-polymer		26.0	1	Chemie (CYN) PubChem (5975)
6	J (A)	5-methyl-L-tryptophan	non-polymer		218.3	1	Chemie (D0Q)
7	K (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA) PubChem (923)
8	L (A)	water	water		18.0	103	Chemie (HOH)

Sequence modifications

A: 1 - 366 (UniProt: P0AEY0)

PDB	External Database	Details
Met -17	-	initiating methionine
Gly -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Met 0	-	expression tag
Val 312	Ala 338	conflict

A: 367 - 764 (UniProt: Q6ZQW0)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	86825.9
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	9
	Total formula weight	1194.1
All*	Total formula weight	88362.2

*Water molecules are not included.