9UZ1
Crystal structure of the indoleamine 2,3-dioxygenagse 2 (IDO2) H143Y mutant complexed with L-Trp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maltose/maltodextrin-binding periplasmic protein,Indoleamine 2,3-dioxygenase 2 | polymer | 782 | 86850.9 | 1 | UniProt (P0AEY0) UniProt (Q6ZQW0) | Homo sapiens (human) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,IDO-2,Indoleamine 2,3-dioxygenase-like protein 1,Indoleamine-pyrrole 2 |
| 2 | B (B) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | |||
| 3 | C (A) | TRYPTOPHAN | non-polymer | 204.2 | 1 | Chemie (TRP) | |||
| 4 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 5 | E (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) PubChem (311) | |||
| 6 | F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 7 | H (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 8 | I (A) | CYANIDE ION | non-polymer | 26.0 | 1 | Chemie (CYN) PubChem (5975) | |||
| 9 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 10 | K (A) | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A: 1 - 366 (UniProt: P0AEY0)
A: 367 - 764 (UniProt: Q6ZQW0)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| Ser -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Asn -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Met 0 | - | expression tag |
| Val 312 | Ala 338 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Tyr 487 | His 130 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 86850.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1292.1 | |
| All* | Total formula weight | 88485.3 |
