9UY3

Anamorelin bound growth hormone secretagogue receptor in complex with Gq

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Engineered G-alpha-q subunit	polymer	362	41855.6	1		Homo sapiens
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	371	40227.0	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (N)	NB35	polymer	140	15343.0	1		Lama glama
5	E (R)	Soluble cytochrome b562,Growth hormone secretagogue receptor type 1,Soluble cytochrome b562,Growth hormone secretagogue receptor type 1,Soluble cytochrome b562,Growth hormone secretagogue receptor type 1,Soluble cytochrome b562,Growth hormone secretagogue receptor type 1,human growth hormone secretagogue receptor	polymer	676	76149.7	1	UniProt (P0ABE7) UniProt (Q92847) Pfam (PF00001) Pfam (PF07361)	Escherichia coli	Cytochrome b-562,GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor
6	F, G (R)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR)
7	H (R)	2-azanyl-N-[(2R)-1-[(3S)-3-[dimethylamino(methyl)carbamoyl]-3-(phenylmethyl)piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxidanylidene-propan-2-yl]-2-methyl-propanamide	non-polymer		546.7	1	Chemie (A1ESD)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -4	-	initiating methionine
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Ser 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
Ser 348	-	expression tag
Gly 349	-	expression tag
Gly 350	-	expression tag
Gly 351	-	expression tag
Gly 352	-	expression tag
Ser 353	-	expression tag
Ser 354	-	expression tag
Gly 355	-	expression tag
Val 356	-	expression tag
Ser 357	-	expression tag
Gly 358	-	expression tag
Trp 359	-	expression tag
Arg 360	-	expression tag
Leu 361	-	expression tag
Phe 362	-	expression tag
Lys 363	-	expression tag
Lys 364	-	expression tag
Ile 365	-	expression tag
Ser 366	-	expression tag

R: -105 - 0 (UniProt: P0ABE7)

PDB	External Database	Details
Met -146	-	initiating methionine
Lys -145	-	expression tag
Thr -144	-	expression tag
Ile -143	-	expression tag
Ile -142	-	expression tag
Ala -141	-	expression tag
Leu -140	-	expression tag
Ser -139	-	expression tag
Tyr -138	-	expression tag
Ile -137	-	expression tag
Phe -136	-	expression tag
Cys -135	-	expression tag
Leu -134	-	expression tag
Val -133	-	expression tag
Phe -132	-	expression tag
Ala -131	-	expression tag
His -130	-	expression tag
His -129	-	expression tag
His -128	-	expression tag
His -127	-	expression tag
His -126	-	expression tag
His -125	-	expression tag
His -124	-	expression tag
His -123	-	expression tag
His -122	-	expression tag
His -121	-	expression tag
Pro -120	-	expression tag
Ser -119	-	expression tag
Arg -118	-	expression tag
Leu -117	-	expression tag
Glu -116	-	expression tag
Glu -115	-	expression tag
Glu -114	-	expression tag
Leu -113	-	expression tag
Arg -112	-	expression tag
Arg -111	-	expression tag
Arg -110	-	expression tag
Leu -109	-	expression tag
Thr -108	-	expression tag
Glu -107	-	expression tag
Pro -106	-	expression tag
Trp -99	Met 29	conflict
Ile -4	His 124	conflict
Leu 0	Arg 128	conflict

R: 1 - 366 (UniProt: Q92847)
R: 367 - 529 (PDB: 9UY3)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	181436.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1320.0
All*	Total formula weight	182756.5

*Water molecules are not included.