9UXU

SalA bound Kappa Opioid Receptor in complex with Gi

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, a)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	353	39020.7	2	UniProt (P54311)	Rattus norvegicus (Norway rat)	Transducin beta chain 1
2	B, E (D, d)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	2	UniProt (P63212)	Bos taurus (domestic cattle)	G gamma-I
3	C, F (R, r)	Kappa-type opioid receptor	polymer	397	44780.1	2	UniProt (P41145)	Homo sapiens (human)	K-OR-1,KOR-1
4	G, H (B, b)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	354	40414.0	2	UniProt (P63096)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein
5	I, J (R, r)	methyl (2~{S},4~{a}~{R},6~{a}~{R},7~{R},9~{S},10~{a}~{S},10~{b}~{R})-9-acetyloxy-2-(furan-3-yl)-6~{a},10~{b}-dimethyl-4,10-bis(oxidanylidene)-2,4~{a},5,6,7,8,9,10~{a}-octahydro-1~{H}-benzo[f]isochromene-7-carboxylate	non-polymer		432.5	2	Chemie (A1EQK)
6	K, L (r)	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	2	Chemie (Y01) PubChem (65082)
7	M, N (r)	CHOLESTEROL	non-polymer		386.7	2	Chemie (CLR) PubChem (5997)

Sequence modifications

A, a: 2 - 340 (UniProt: P54311)

PDB	External Database	Details
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
Met -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

R, r: 3 - 380 (UniProt: P41145)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Ala 1	-	expression tag
Ser 2	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag

B, b: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Asn 47	Ser 47	conflict
Ala 203	Gly 203	conflict
Ala 245	Glu 245	conflict
Ser 326	Ala 326	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	264151.8
Non-Polymers*	Number of molecules	6
	Total formula weight	2611.7
All*	Total formula weight	266763.5

*Water molecules are not included.