9UWQ
A combined Cryo_EM structure of Cagrilintide-AMY1R-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein g(s) subunit alpha | polymer | 361 | 41879.5 | 1 | Homo sapiens | ||
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 366 | 39728.4 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (D) | Cagrilintide | polymer | 37 | 3962.4 | 1 | Homo sapiens | ||
| 4 | D (E) | Receptor activity-modifying protein 1 | polymer | 122 | 13971.1 | 1 | UniProt (O60894) | Homo sapiens (human) | Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1 |
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 6 | F (R) | Calcitonin receptor | polymer | 450 | 52616.0 | 1 | UniProt (P30988) | Homo sapiens (human) | CT-R |
Sequence modifications
C: 1 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 160018.6 | |
| All* | Total formula weight | 160018.6 |
