9UWL
Cryo-EM structure of human V1aR bound with SRX246 at a resolution of 2.6 angstrom
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Vasopressin V1a receptor | polymer | 386 | 43695.1 | 2 | UniProt (P37288) | Homo sapiens (human) | V1aR,AVPR V1a,Antidiuretic hormone receptor 1a,Vascular/hepatic-type arginine vasopressin receptor |
| 2 | C, F (A, B) | SRX246 | non-polymer | 703.9 | 2 | Chemie (A1EQN) | |||
| 3 | D, E, G, H (A, B) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 418 (UniProt: P37288)
| PDB | External Database | Details |
|---|---|---|
| Cys 341 | Ser 341 | engineered mutation |
| Lys 344 | Asn 344 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87390.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2954.4 | |
| All* | Total formula weight | 90344.5 |
