9UVY

Cryo-EM structure of Vasopressin receptor 2 (V2R)-ARK1 with tolvaptan

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Vasopressin V2 receptor,ARK1	polymer	765	86251.1	1	UniProt (P30518) Pfam (PF00001)	Homo sapiens (human)	V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor
2	B (A)	(R)-Tolvaptan	non-polymer		448.9	1	Chemie (A1IT8) PubChem (216237) PubChem (443894) PubChem (10789661)
3	C (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 235 (UniProt: P30518)

PDB	External Database	Details
Met -30	-	initiating methionine
Lys -29	-	expression tag
Thr -28	-	expression tag
Ile -27	-	expression tag
Ile -26	-	expression tag
Ala -25	-	expression tag
Leu -24	-	expression tag
Ser -23	-	expression tag
Tyr -22	-	expression tag
Ile -21	-	expression tag
Phe -20	-	expression tag
Cys -19	-	expression tag
Leu -18	-	expression tag
Val -17	-	expression tag
Phe -16	-	expression tag
Ala -15	-	expression tag
Asp -14	-	expression tag
Tyr -13	-	expression tag
Lys -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Ala -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

A: 236 - 622 (PDB: 9UVY)
A: 623 - 728 (UniProt: P30518)

PDB	External Database	Details
Leu 729	-	expression tag
Glu 730	-	expression tag
Val 731	-	expression tag
Leu 732	-	expression tag
Phe 733	-	expression tag
Gln 734	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	86251.1
Non-Polymers*	Number of molecules	1
	Total formula weight	448.9
All*	Total formula weight	86700.1

*Water molecules are not included.