9UVT
Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Heavy chain of anti-BRIL SRP2070 fab antibody | polymer | 290 | 31421.2 | 1 | Mus musculus | ||
| 2 | B (L) | Light chain of anti-BRIL SRP2070 fab antibody | polymer | 235 | 26065.0 | 1 | Mus musculus | ||
| 3 | C (A) | B2 bradykinin receptor,Soluble cytochrome b562 | polymer | 487 | 54839.9 | 1 | UniProt (P30411) UniProt (P0ABE7) Pfam (PF00001) | Homo sapiens (human) | B2R,BK-2 receptor,Cytochrome b-562 |
| 4 | D (B) | icatibant | polymer | 10 | 1307.5 | 1 | synthetic construct |
Sequence modifications
A: 11 - 251 (UniProt: P30411)
A: 252 - 357 (UniProt: P0ABE7)
A: 358 - 489 (UniProt: P30411)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | - | expression tag |
| Pro 10 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 258 | Met 29 | engineered mutation |
| Ile 353 | His 124 | engineered mutation |
| Leu 357 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 490 | - | expression tag |
| Glu 491 | - | expression tag |
| Val 492 | - | expression tag |
| Leu 493 | - | expression tag |
| Phe 494 | - | expression tag |
| Gln 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113633.6 | |
| All* | Total formula weight | 113633.6 |
