9UT6

The helicase module of the helicase-primase complex from HHV1 bound with ssDNA and pritelivir

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	synthetic DNA	polymer	6	1780.2	1		synthetic construct
2	B (A)	DNA replication helicase	polymer	934	104354.2	1	UniProt (P10189)	Human alphaherpesvirus 1 (Herpes simplex virus type 1)
3	C (B)	Ubiquitin-like protein SMT3,DNA primase	polymer	1195	130399.0	1	UniProt (Q12306) UniProt (P10236)	Saccharomyces cerevisiae S288C
4	D (B)	Pritelivir	non-polymer		402.5	1	Chemie (A1BXB) PubChem (491941)
5	E (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 1 - 882 (UniProt: P10189)

PDB	External Database	Details
Met -51	-	initiating methionine
Ser -50	-	expression tag
Tyr -49	-	expression tag
Tyr -48	-	expression tag
Gly -47	-	expression tag
Ala -46	-	expression tag
Trp -45	-	expression tag
Ser -44	-	expression tag
His -43	-	expression tag
Pro -42	-	expression tag
Gln -41	-	expression tag
Phe -40	-	expression tag
Glu -39	-	expression tag
Lys -38	-	expression tag
Gly -37	-	expression tag
Gly -36	-	expression tag
Gly -35	-	expression tag
Ser -34	-	expression tag
Gly -33	-	expression tag
Gly -32	-	expression tag
Gly -31	-	expression tag
Ser -30	-	expression tag
Gly -29	-	expression tag
Gly -28	-	expression tag
Ser -27	-	expression tag
Ala -26	-	expression tag
Trp -25	-	expression tag
Ser -24	-	expression tag
His -23	-	expression tag
Pro -22	-	expression tag
Gln -21	-	expression tag
Phe -20	-	expression tag
Glu -19	-	expression tag
Lys -18	-	expression tag
Gly -17	-	expression tag
Ala -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

B: -95 - 0 (UniProt: Q12306)

PDB	External Database	Details
Met -136	-	initiating methionine
Ser -135	-	expression tag
Tyr -134	-	expression tag
Tyr -133	-	expression tag
His -132	-	expression tag
His -131	-	expression tag
His -130	-	expression tag
His -129	-	expression tag
His -128	-	expression tag
His -127	-	expression tag
Asp -126	-	expression tag
Tyr -125	-	expression tag
Asp -124	-	expression tag
Ile -123	-	expression tag
Pro -122	-	expression tag
Thr -121	-	expression tag
Thr -120	-	expression tag
Glu -119	-	expression tag
Asn -118	-	expression tag
Leu -117	-	expression tag
Tyr -116	-	expression tag
Phe -115	-	expression tag
Gln -114	-	expression tag
Gly -113	-	expression tag
Ile -112	-	expression tag
Thr -111	-	expression tag
Ser -110	-	expression tag
Leu -109	-	expression tag
Tyr -108	-	expression tag
Lys -107	-	expression tag
Lys -106	-	expression tag
Ala -105	-	expression tag
Gly -104	-	expression tag
Phe -103	-	expression tag
Leu -102	-	expression tag
Gln -101	-	expression tag
Leu -100	-	expression tag
Gly -99	-	expression tag
Ser -98	-	expression tag
Leu -97	-	expression tag
Gln -96	-	expression tag
Thr -34	Arg 64	engineered mutation
Glu -27	Arg 71	engineered mutation

B: 1 - 1058 (UniProt: P10236)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	236533.3
Non-Polymers*	Number of molecules	2
	Total formula weight	467.9
All*	Total formula weight	237001.2

*Water molecules are not included.