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9USB

GppNHp-bound KRAS G12D in complex with MCB-294

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)
Isoform 2B of GTPase KRaspolymer17519714.23UniProt (P01116)
Pfam (PF00071)
Homo sapiens (human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2D, G, J
(A, B, C)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
3E, H, K
(A, B, C)
(3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-olnon-polymer633.63Chemie (A1EN3)
4F, I, L
(A, B, C)
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERnon-polymer522.23Chemie (GNP)
5M, N, O
(A, B, C)
waterwater18.074Chemie (HOH)
Sequence modifications
A, B, C: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Gly -5-expression tag
Ala -4-expression tag
Gly -3-expression tag
Ala -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Asp 12Gly 12variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight59142.6
Non-Polymers*Number of molecules9
Total formula weight3540.4
All*Total formula weight62683.0
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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