9UOU

Crystal structure of the fusion protein of T-lineage protein Themis and adaptor protein Grb2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Protein THEMIS,Growth factor receptor-bound protein 2	polymer	648	74246.6	2	UniProt (Q8N1K5) UniProt (P62993) Pfam (PF12736) Pfam (PF00018)	Homo sapiens (human)	Thymocyte-expressed molecule involved in selection,Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2

Sequence modifications

B, A: 1 - 561 (UniProt: Q8N1K5)

PDB	External Database	Details
Met -23	-	initiating methionine
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
Ser -16	-	expression tag
Ser -15	-	expression tag
Gly -14	-	expression tag
Val -13	-	expression tag
Asp -12	-	expression tag
Leu -11	-	expression tag
Gly -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag
Gly 562	-	linker
Gly 563	-	linker
Ser 564	-	linker
Gly 565	-	linker
Gly 566	-	linker
Ser 567	-	linker

B, A: 568 - 624 (UniProt: P62993)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	148493.2
All*	Total formula weight	148493.2

*Water molecules are not included.