9UO4

Cryo-EM structure of the chimeric human IgM-Fc hexamer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Immunoglobulin heavy constant mu	polymer	376	41103.0	12	UniProt (P01871) Pfam (PF07654)	Homo sapiens (human)	Ig mu chain C region,Ig mu chain C region BOT,Ig mu chain C region GAL,Ig mu chain C region OU

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 229 - 556 (UniProt: P01871)

PDB	External Database	Details
Ala 194	-	expression tag
Ser 195	-	expression tag
Ala 196	-	expression tag
Trp 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
Pro 200	-	expression tag
Gln 201	-	expression tag
Phe 202	-	expression tag
Glu 203	-	expression tag
Lys 204	-	expression tag
Gly 205	-	expression tag
Gly 206	-	expression tag
Gly 207	-	expression tag
Ser 208	-	expression tag
Gly 209	-	expression tag
Gly 210	-	expression tag
Gly 211	-	expression tag
Ser 212	-	expression tag
Gly 213	-	expression tag
Gly 214	-	expression tag
Ser 215	-	expression tag
Ala 216	-	expression tag
Trp 217	-	expression tag
Ser 218	-	expression tag
His 219	-	expression tag
Pro 220	-	expression tag
Gln 221	-	expression tag
Phe 222	-	expression tag
Glu 223	-	expression tag
Lys 224	-	expression tag
Ile 225	-	expression tag
Asp 226	-	expression tag
Thr 227	-	expression tag
Thr 228	-	expression tag
Gly 557	-	expression tag
Lys 558	-	expression tag
Ser 559	-	expression tag
Ser 560	-	expression tag
Leu 561	-	expression tag
Val 562	-	expression tag
Asn 563	-	expression tag
Val 564	-	expression tag
Asn 565	-	expression tag
Leu 566	-	expression tag
Val 567	-	expression tag
Met 568	-	expression tag
Ser 569	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	493235.4
All*	Total formula weight	493235.4

*Water molecules are not included.