9UE6

Cryo-EM structure of SARS-CoV-2 KP.2 spike RBD in complex with ACE2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Spike protein S1	polymer	195	22072.9	1	UniProt (P0DTC2)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
2	B (B)	Angiotensin-converting enzyme 2	polymer	631	72989.0	1	UniProt (Q9BYF1)	Homo sapiens (human)	Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15

Sequence modifications

A: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
His 339	Gly 339	variant
Thr 346	Arg 346	variant
Thr 356	Lys 356	conflict
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Lys 403	Arg 403	conflict
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
His 445	Val 445	conflict
Ser 446	Gly 446	variant
Asp 450	Asn 450	conflict
Trp 452	Leu 452	conflict
Ser 455	Leu 455	conflict
Leu 456	Phe 456	variant
Lys 460	Asn 460	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Lys 481	Asn 481	conflict
-	Val 483	deletion
Lys 484	Glu 484	variant
Pro 486	Phe 486	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant

B: 1 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
Leu 616	-	expression tag
Glu 617	-	expression tag
Val 618	-	expression tag
Leu 619	-	expression tag
Phe 620	-	expression tag
Gln 621	-	expression tag
Gly 622	-	expression tag
Pro 623	-	expression tag
His 624	-	expression tag
His 625	-	expression tag
His 626	-	expression tag
His 627	-	expression tag
His 628	-	expression tag
His 629	-	expression tag
His 630	-	expression tag
His 631	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95062.0
All*	Total formula weight	95062.0

*Water molecules are not included.