9UDM
Cocrystal structure of human cytosolic phenylalanyl-tRNA synthetase and an inhibitor in the presence of ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phenylalanine--tRNA ligase alpha subunit | polymer | 314 | 36433.4 | 1 | UniProt (Q9Y285) Pfam (PF01409) | Homo sapiens (human) | CML33,Phenylalanyl-tRNA synthetase alpha subunit,PheRS |
| 2 | B (B) | Phenylalanine--tRNA ligase beta subunit | polymer | 589 | 66214.5 | 1 | UniProt (Q9NSD9) Pfam (PF18262) Pfam (PF03483) Pfam (PF03484) Pfam (PF17759) | Homo sapiens (human) | Phenylalanyl-tRNA synthetase beta subunit,PheRS |
| 3 | C (A) | [6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID | non-polymer | 379.9 | 1 | Chemie (LCF) PubChem (133021) |
Sequence modifications
A: 187 - 490 (UniProt: Q9Y285)
B: 1 - 589 (UniProt: Q9NSD9)
| PDB | External Database | Details |
|---|---|---|
| Met 177 | - | initiating methionine |
| Gly 178 | - | expression tag |
| Ser 179 | - | expression tag |
| Ser 180 | - | expression tag |
| His 181 | - | expression tag |
| His 182 | - | expression tag |
| His 183 | - | expression tag |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 585 | Val 585 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 102647.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 379.9 | |
| All* | Total formula weight | 103027.8 |
