9UBW
The atomic coordinates of the mouse CatSper dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, a) | Cation channel sperm-associated protein 1 | polymer | 251 | 29080.7 | 2 | UniProt (Q91ZR5) Pfam (PF00520) | Mus musculus (house mouse) | CatSper1 |
| 2 | B, P (B, b) | Cation channel sperm-associated protein 2 | polymer | 281 | 33115.5 | 2 | UniProt (A2ARP9) Pfam (PF00520) | Mus musculus (house mouse) | CatSper2 |
| 3 | C, Q (C, c) | Cation channel sperm-associated protein 3 | polymer | 278 | 32308.9 | 2 | UniProt (Q80W99) Pfam (PF00520) | Mus musculus (house mouse) | CatSper3 |
| 4 | D, R (D, d) | Cation channel sperm-associated protein 4 | polymer | 250 | 28880.4 | 2 | UniProt (Q8BVN3) Pfam (PF00520) | Mus musculus (house mouse) | CatSper4 |
| 5 | E, S (E, e) | Cation channel sperm-associated auxiliary subunit beta | polymer | 1065 | 121580.6 | 2 | UniProt (A2RTF1) Pfam (PF21541) Pfam (PF21548) Pfam (PF22830) Pfam (PF22831) Pfam (PF15149) | Mus musculus (house mouse) | CatSper-beta |
| 6 | F, T (F, f) | Cation channel sperm-associated auxiliary subunit gamma 2 | polymer | 1042 | 119864.4 | 2 | UniProt (C6KI89) Pfam (PF22840) Pfam (PF15064) Pfam (PF22851) Pfam (PF22846) | Mus musculus (house mouse) | |
| 7 | G, U (G, g) | Cation channel sperm-associated auxiliary subunit delta | polymer | 733 | 82834.3 | 2 | UniProt (E9Q9F6) Pfam (PF15020) Pfam (PF23747) Pfam (PF22850) | Mus musculus (house mouse) | CatSper-delta,CatSperdelta,Transmembrane protein 146 |
| 8 | H, V (H, h) | Cation channel sperm-associated auxiliary subunit epsilon | polymer | 921 | 107004.0 | 2 | UniProt (P0DP43) Pfam (PF22841) Pfam (PF22843) Pfam (PF22844) Pfam (PF22849) Pfam (PF22850) | Mus musculus (house mouse) | CatSper-epsilon,CatSperepsilon,C1orf101-like protein |
| 9 | I, W (I, i) | EF-hand calcium-binding domain-containing protein 9 | polymer | 174 | 20942.3 | 2 | UniProt (Q9DAM2) | Mus musculus (house mouse) | |
| 10 | J, X (J, j) | Cation channel sperm-associated auxiliary subunit TMEM249 | polymer | 168 | 19898.6 | 2 | UniProt (A0A2R8VHF7) Pfam (PF15158) | Mus musculus (house mouse) | Transmembrane protein 249 |
| 11 | K, Y (K, k) | Cation channel sperm-associated auxiliary subunit zeta | polymer | 149 | 17504.6 | 2 | UniProt (Q9CQP8) | Mus musculus (house mouse) | CatSper-zeta,CatSperzeta,Protein expressed in male leptotene and zygotene spermatocytes 622,MLZ-622,Testis-expressed protein 40 |
| 12 | L, Z (L, l) | Solute carrier organic anion transporter family member 6C1 | polymer | 610 | 68349.7 | 2 | UniProt (Q8C0X7) Pfam (PF03137) Pfam (PF07648) | Mus musculus (house mouse) | |
| 13 | AA, M (M, m) | Cation channel sperm-associated auxiliary subunit TMEM262 | polymer | 115 | 13350.9 | 2 | UniProt (D3Z338) | Mus musculus (house mouse) | Cation channel sperm-associated auxiliary subunit eta,Transmembrane protein 262 |
| 14 | BA, N (N, n) | Unknown protein | polymer | 28 | 2401.0 | 2 | Mus musculus | ||
| 15 | CA, MA (O, Y) | beta-D-mannopyranose-(1-2)-beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G01504UZ) | |||
| 16 | DA, EA, GA, HA, IA... (P, Q, S, T, U...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 10 | In PDB GlyTouCan (G15407YE) | |||
| 17 | FA, KA, PA, UA (R, W, p, u) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 18 | JA, TA (V, t) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 2 | In PDB GlyTouCan (G42553TN) | |||
| 19 | LA, VA (X, v) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G89225LT) | |||
| 20 | AB, BB, CB, DB, EB... (E, F, G, e, f...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) | |||
| 21 | FB, PB (M, m) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) |
Sequence modifications
J, j: 24 - 168 (UniProt: A0A2R8VHF7)
L, l: 81 - 690 (UniProt: Q8C0X7)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Cys 2 | - | expression tag |
| Trp 3 | - | expression tag |
| Val 4 | - | expression tag |
| Met 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Pro 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Val 9 | - | expression tag |
| Phe 10 | - | expression tag |
| Val 11 | - | expression tag |
| Leu 12 | - | expression tag |
| Glu 13 | - | expression tag |
| Tyr 14 | - | expression tag |
| Tyr 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Asp 17 | - | expression tag |
| Thr 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Trp 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Gly 22 | - | expression tag |
| Thr 23 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 224 | Ala 224 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 1394231.4 | |
| Branched | Number of molecules | 20 |
| Total formula weight | 14325.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 4755.1 | |
| All* | Total formula weight | 1413311.6 |
