9U9V

beta2-adrenergic receptor in complex with methamphetamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	394	45683.4	1	UniProt (P63092) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-stimulating G alpha protein
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	351	38744.4	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)	Transducin beta chain 1
3	C (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7845.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (N)	Nb35 nanobody	polymer	162	17540.7	1		Homo sapiens (human)
5	E (R)	Beta-2 adrenergic receptor	polymer	413	46666.2	1	UniProt (P07550) Pfam (PF00001)	Homo sapiens (human)	Beta-2 adrenoreceptor,Beta-2 adrenoceptor
6	F (R)	(2S)-N-methyl-1-phenylpropan-2-amine	non-polymer		149.2	1	Chemie (B40)

Sequence modifications

A: 1 - 394 (UniProt: P63092)

PDB	External Database	Details
Asn 54	Ser 54	conflict
Ala 226	Gly 226	conflict
Ala 268	Glu 268	conflict
Lys 271	Asn 271	conflict
Asp 274	Lys 274	conflict
Lys 280	Arg 280	conflict
Asp 284	Thr 284	conflict
Thr 285	Ile 285	conflict

B: 13 - 351 (UniProt: P62873)

PDB	External Database	Details
Met 1	-	initiating methionine
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Gln 12	-	expression tag

C: 1 - 71 (UniProt: P59768)

PDB	External Database	Details
Ser 68	Cys 68	conflict

R: 1 - 348 (UniProt: P07550)

PDB	External Database	Details
Met -18	-	initiating methionine
Lys -17	-	expression tag
Thr -16	-	expression tag
Ile -15	-	expression tag
Ile -14	-	expression tag
Ala -13	-	expression tag
Leu -12	-	expression tag
Ser -11	-	expression tag
Tyr -10	-	expression tag
Ile -9	-	expression tag
Phe -8	-	expression tag
Cys -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Phe -4	-	expression tag
Ala -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Pro 0	-	expression tag
Trp 122	Glu 122	conflict
Glu 349	-	expression tag
Phe 350	-	expression tag
Leu 351	-	expression tag
Glu 352	-	expression tag
Val 353	-	expression tag
Leu 354	-	expression tag
Phe 355	-	expression tag
Gln 356	-	expression tag
Gly 357	-	expression tag
Pro 358	-	expression tag
Trp 359	-	expression tag
Ser 360	-	expression tag
His 361	-	expression tag
Pro 362	-	expression tag
Gln 363	-	expression tag
Phe 364	-	expression tag
Glu 365	-	expression tag
Lys 366	-	expression tag
Gly 367	-	expression tag
Gly 368	-	expression tag
Gly 369	-	expression tag
Ser 370	-	expression tag
Gly 371	-	expression tag
Gly 372	-	expression tag
Gly 373	-	expression tag
Ser 374	-	expression tag
Gly 375	-	expression tag
Gly 376	-	expression tag
Ser 377	-	expression tag
Ala 378	-	expression tag
Trp 379	-	expression tag
Ser 380	-	expression tag
His 381	-	expression tag
Pro 382	-	expression tag
Gln 383	-	expression tag
Phe 384	-	expression tag
Glu 385	-	expression tag
Lys 386	-	expression tag
Asp 387	-	expression tag
Tyr 388	-	expression tag
Lys 389	-	expression tag
Asp 390	-	expression tag
Asp 391	-	expression tag
Asp 392	-	expression tag
Asp 393	-	expression tag
Lys 394	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	156479.8
Non-Polymers*	Number of molecules	1
	Total formula weight	149.2
All*	Total formula weight	156629.0

*Water molecules are not included.