9U91
Complex of compound 31r and EGFR Del19/T790M/C797S/V948R
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 344 | 39412.7 | 1 | UniProt (P00533) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | N-[6-[[2-[[5-ethyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]quinoxalin-5-yl]-N-methyl-methanesulfonamide | non-polymer | 699.9 | 1 | Chemie (A1EOG) | |||
| 3 | C (A) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 680 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 679 | - | expression tag |
| - | Glu 746 | deletion |
| - | Leu 747 | deletion |
| - | Arg 748 | deletion |
| - | Glu 749 | deletion |
| - | Ala 750 | deletion |
| Met 790 | Thr 790 | engineered mutation |
| Ser 797 | Cys 797 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39412.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 699.9 | |
| All* | Total formula weight | 40112.5 |
