9U8C
Crystal structure of EGFR exon20 insertion mutant in complex with enozertinib (ORIC-114)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Epidermal growth factor receptor | polymer | 338 | 38451.4 | 5 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | F, G, H, I (A, B, C, D) | ~{N}-[5-[[6-[(3~{R})-3-[3,5-bis(fluoranyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-phenyl]propanamide | non-polymer | 662.8 | 4 | Chemie (A1L8T) |
Sequence modifications
A, B, C, D, E: 696 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 688 | - | expression tag |
| Ala 689 | - | expression tag |
| Met 690 | - | expression tag |
| Asp 691 | - | expression tag |
| Pro 692 | - | expression tag |
| Glu 693 | - | expression tag |
| Phe 694 | - | expression tag |
| Met 695 | - | expression tag |
| Asn 771 | - | insertion |
| Pro 772 | - | insertion |
| Gly 773 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 192257.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2651.1 | |
| All* | Total formula weight | 194908.1 |
