9U81
Cryo-EM structure of tolvaptan-bound human vasopressin V2 receptor complex with Fab
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | anti-BRIL Fab heavy chain | polymer | 229 | 24321.1 | 1 | Homo sapiens (human) | ||
| 2 | B (L) | anti-BRIL Fab light chain | polymer | 216 | 23586.2 | 1 | Homo sapiens (human) | ||
| 3 | C (R) | Vasopressin V2 receptor,Soluble cytochrome b562 | polymer | 460 | 50571.6 | 1 | UniProt (P30518) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (human) | V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor,Cytochrome b-562 |
| 4 | D (R) | Tolvaptan | non-polymer | 448.9 | 1 | Chemie (A1ECF) |
Sequence modifications
R: 33 - 234 (UniProt: P30518)
R: 1005 - 1109 (UniProt: P0ABE7)
R: 264 - 371 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Leu 2 | - | expression tag |
| Met 3 | - | expression tag |
| Ala 4 | - | expression tag |
| Ser 5 | - | expression tag |
| Thr 6 | - | expression tag |
| Thr 7 | - | expression tag |
| Ser 8 | - | expression tag |
| Ala 9 | - | expression tag |
| Val 10 | - | expression tag |
| Pro 11 | - | expression tag |
| Gly 12 | - | expression tag |
| His 13 | - | expression tag |
| Pro 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Pro 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Asn 22 | - | expression tag |
| Ser 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Gln 25 | - | expression tag |
| Glu 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Pro 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Thr 31 | - | expression tag |
| Arg 32 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Trp 1011 | Met 29 | conflict |
| Ile 1106 | His 124 | conflict |
| Leu 1110 | - | linker |
| Glu 1111 | - | linker |
| Arg 1112 | - | linker |
| Ala 1113 | - | linker |
| Arg 1114 | - | linker |
| Ser 1115 | - | linker |
| Thr 1116 | - | linker |
| Leu 1117 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 1000 | - | linker |
| Arg 1001 | - | linker |
| Arg 1002 | - | linker |
| Gln 1003 | - | linker |
| Leu 1004 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98478.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 448.9 | |
| All* | Total formula weight | 98927.8 |
