9U7G

FGFR1 kinase domain with a macrocyclic compound 8g

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fibroblast growth factor receptor 1	polymer	310	35264.5	2	UniProt (P11362)	Homo sapiens (human)	FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2	C, F (A, B)	(E)-4-methyl-17-(1-methyl-1H-pyrazol-4-yl)-7,10-dioxa-4-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridinacyclodecaphan-3-one	non-polymer		419.4	2	Chemie (A1EOH)
3	D, E (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	G, H (A, B)	water	water		18.0	532	Chemie (HOH)

Sequence modifications

A, B: 458 - 765 (UniProt: P11362)

PDB	External Database	Details
Gly 456	-	expression tag
Pro 457	-	expression tag
Ser 584	Cys 584	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70529.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1031.0
All*	Total formula weight	71560.0

*Water molecules are not included.