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9U5T

GDP-bound KRAS G12D in complex with MCB-294

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Isoform 2B of GTPase KRaspolymer17519714.21UniProt (P01116)
Pfam (PF00071)
Homo sapiens (human)K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2B
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
3C
(A)
(3~{R})-1-[2-[[(8~{S})-6-[bis(fluoranyl)methylidene]-2,3,5,7-tetrahydro-1~{H}-pyrrolizin-8-yl]methoxy]-7-(8-ethynyl-7-fluoranyl-3-oxidanyl-naphthalen-1-yl)-8-fluoranyl-pyrido[4,3-d]pyrimidin-4-yl]-3-methyl-piperidin-3-olnon-polymer633.61Chemie (A1EN3)
4D
(A)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
5E
(A)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
6F
(A)
waterwater18.0182Chemie (HOH)
Sequence modifications
A: 1 - 169 (UniProt: P01116)
PDBExternal DatabaseDetails
Gly -5-expression tag
Ala -4-expression tag
Gly -3-expression tag
Ala -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Asp 12Gly 12variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight19714.2
Non-Polymers*Number of molecules4
Total formula weight1207.3
All*Total formula weight20921.4
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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