9U4Y
cryo-EM structure of Xenopus laevis GnRHR bound with mammal GnRH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37784.3 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 3 | C (C) | Gonadoliberin-1 | polymer | 11 | 1183.3 | 1 | UniProt (Q28588) Pfam (PF00446) | synthetic construct | |
| 4 | D (A) | Guanine nucleotide-binding protein G(q) subunit alpha-1 | polymer | 246 | 28084.8 | 1 | Homo sapiens (human) | ||
| 5 | E (S) | scFv16 | polymer | 285 | 30363.0 | 1 | Homo sapiens (human) | ||
| 6 | F (R) | Beta-2 adrenergic receptor,Gonadotropin-releasing hormone receptor | polymer | 504 | 56891.4 | 1 | UniProt (P07550) UniProt (Q90WJ2) Pfam (PF00001) | Ateles | Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
Sequence modifications
B: 7 - 345 (UniProt: P62873)
C: 1 - 10 (UniProt: Q28588)
R: -38 - -9 (UniProt: P07550)
R: 1 - 418 (UniProt: Q90WJ2)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Gln 6 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Nh2 11 | - | amidation |
| PDB | External Database | Details |
|---|---|---|
| Met -85 | - | initiating methionine |
| Asp -84 | - | expression tag |
| Ser -83 | - | expression tag |
| Lys -82 | - | expression tag |
| Gly -81 | - | expression tag |
| Ser -80 | - | expression tag |
| Ser -79 | - | expression tag |
| Gln -78 | - | expression tag |
| Lys -77 | - | expression tag |
| Gly -76 | - | expression tag |
| Ser -75 | - | expression tag |
| Arg -74 | - | expression tag |
| Leu -73 | - | expression tag |
| Leu -72 | - | expression tag |
| Leu -71 | - | expression tag |
| Leu -70 | - | expression tag |
| Leu -69 | - | expression tag |
| Val -68 | - | expression tag |
| Val -67 | - | expression tag |
| Ser -66 | - | expression tag |
| Asn -65 | - | expression tag |
| Leu -64 | - | expression tag |
| Leu -63 | - | expression tag |
| Leu -62 | - | expression tag |
| Cys -61 | - | expression tag |
| Gln -60 | - | expression tag |
| Gly -59 | - | expression tag |
| Val -58 | - | expression tag |
| Val -57 | - | expression tag |
| Ser -56 | - | expression tag |
| Asp -55 | - | expression tag |
| Tyr -54 | - | expression tag |
| Lys -53 | - | expression tag |
| Asp -52 | - | expression tag |
| Asp -51 | - | expression tag |
| Asp -50 | - | expression tag |
| Asp -49 | - | expression tag |
| Val -48 | - | expression tag |
| His -47 | - | expression tag |
| His -46 | - | expression tag |
| His -45 | - | expression tag |
| His -44 | - | expression tag |
| His -43 | - | expression tag |
| His -42 | - | expression tag |
| His -41 | - | expression tag |
| His -40 | - | expression tag |
| Asp -39 | - | expression tag |
| Gln -12 | Glu 27 | conflict |
| Glu -8 | - | linker |
| Asn -7 | - | linker |
| Leu -6 | - | linker |
| Tyr -5 | - | linker |
| Phe -4 | - | linker |
| Gln -3 | - | linker |
| Gly -2 | - | linker |
| Ala -1 | - | linker |
| Ser 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 162168.1 | |
| All* | Total formula weight | 162168.1 |
