9U4O

Cryo-EM Structure of Human ACE2 Complexed with RacCS20637 RBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Processed angiotensin-converting enzyme 2	polymer	637	73322.7	1	UniProt (Q9BYF1)	Homo sapiens (human)
2	B (B)	Spike glycoprotein	polymer	248	28079.8	1	UniProt (A0AAN0NP16)	Coronaviridae
3	C, D, G (C, D, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	E, F (E, F)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	H, I (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)

Sequence modifications

A: 19 - 615 (UniProt: Q9BYF1)

PDB	External Database	Details
Met -12	-	initiating methionine
Gly -11	-	expression tag
Ile -10	-	expression tag
Leu -9	-	expression tag
Pro -8	-	expression tag
Ser -7	-	expression tag
Pro -6	-	expression tag
Gly -5	-	expression tag
Met -4	-	expression tag
Pro -3	-	expression tag
Ala -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Ser 1	-	expression tag
Leu 2	-	expression tag
Val 3	-	expression tag
Ser 4	-	expression tag
Leu 5	-	expression tag
Leu 6	-	expression tag
Ser 7	-	expression tag
Val 8	-	expression tag
Leu 9	-	expression tag
Leu 10	-	expression tag
Met 11	-	expression tag
Gly 12	-	expression tag
Cys 13	-	expression tag
Val 14	-	expression tag
Ala 15	-	expression tag
Glu 16	-	expression tag
Thr 17	-	expression tag
Gly 18	-	expression tag
Gly 616	-	expression tag
Thr 617	-	expression tag
Lys 618	-	expression tag
His 619	-	expression tag
His 620	-	expression tag
His 621	-	expression tag
His 622	-	expression tag
His 623	-	expression tag
His 624	-	expression tag

B: 319 - 541 (UniProt: A0AAN0NP16)

PDB	External Database	Details
Met 300	-	initiating methionine
Glu 301	-	expression tag
Thr 302	-	expression tag
Gly 303	-	expression tag
Leu 304	-	expression tag
Arg 305	-	expression tag
Trp 306	-	expression tag
Leu 307	-	expression tag
Leu 308	-	expression tag
Leu 309	-	expression tag
Val 310	-	expression tag
Ala 311	-	expression tag
Val 312	-	expression tag
Leu 313	-	expression tag
Lys 314	-	expression tag
Gly 315	-	expression tag
Val 316	-	expression tag
Gln 317	-	expression tag
Cys 318	-	expression tag
Ile 402	Val 398	conflict
Asn 477	Ser 473	conflict
Glu 478	Thr 474	conflict
Gln 493	Lys 489	conflict
His 542	-	expression tag
His 543	-	expression tag
His 544	-	expression tag
His 545	-	expression tag
His 546	-	expression tag
His 547	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	101402.5
Branched	Number of molecules	5
	Total formula weight	2446.3
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	104291.2

*Water molecules are not included.