9U4D
Structure of UBE3A-E6-p53 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Maltose/maltodextrin-binding periplasmic protein,Protein E6 | polymer | 541 | 61225.5 | 1 | UniProt (P0AEX9) UniProt (P03126) | Escherichia coli (strain K12) | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP |
| 2 | B (C) | Cellular tumor antigen p53 | polymer | 395 | 43865.3 | 1 | UniProt (P04637) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 3 | C (A) | Isoform I of Ubiquitin-protein ligase E3A | polymer | 856 | 98385.8 | 1 | UniProt (Q05086) | Homo sapiens (human) | E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54 |
| 4 | D, E, F (B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) PubChem (32051) |
Sequence modifications
B: -388 - -23 (UniProt: P0AEX9)
B: 1 - 151 (UniProt: P03126)
C: 1 - 393 (UniProt: P04637)
A: 1 - 852 (UniProt: Q05086)
| PDB | External Database | Details |
|---|---|---|
| Met -389 | - | initiating methionine |
| Asn -22 | - | linker |
| Ser -21 | - | linker |
| His -20 | - | linker |
| Met -19 | - | linker |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| Ser -12 | - | linker |
| Ser -11 | - | linker |
| Gly -10 | - | linker |
| Leu -9 | - | linker |
| Glu -8 | - | linker |
| Val -7 | - | linker |
| Leu -6 | - | linker |
| Phe -5 | - | linker |
| Gln -4 | - | linker |
| Gly -3 | - | linker |
| Pro -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 80 | Cys 87 | engineered mutation |
| Ser 97 | Cys 104 | engineered mutation |
| Ser 111 | Cys 118 | engineered mutation |
| Ser 140 | Cys 147 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | linker |
| Pro 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | linker |
| Pro -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 203476.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 203672.9 |
