9U3N
Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 311 | 35669.1 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, D (A, B) | ~{N}-[4-[4-azanyl-7-methyl-5-[2-(3-methylimidazo[4,5-b]pyridin-6-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]prop-2-enamide | non-polymer | 448.5 | 2 | Chemie (A1ENT) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Phe 564 | Val 564 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71338.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 897.0 | |
| All* | Total formula weight | 72235.2 |
