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9U3N

Crystal structure of FGFR2 kinase domain gatekeeper mutant V564F in complex with compound LC-F2-01

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Fibroblast growth factor receptor 2polymer31135669.12UniProt (P21802)
Pfam (PF07714)
Homo sapiens (human)FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2C, D
(A, B)
~{N}-[4-[4-azanyl-7-methyl-5-[2-(3-methylimidazo[4,5-b]pyridin-6-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]prop-2-enamidenon-polymer448.52Chemie (A1ENT)
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
PDBExternal DatabaseDetails
Phe 564Val 564engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight71338.2
Non-Polymers*Number of molecules2
Total formula weight897.0
All*Total formula weight72235.2
*Water molecules are not included.

237423

PDB entries from 2025-06-11

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