9U3L
Substrate-engaged human 26S proteasome bound to midnolin with RPT2 at top of spiral staircase
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 26S proteasome regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2 |
| 2 | B (B) | 26S proteasome regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 3 | C (C) | 26S proteasome regulatory subunit 8 | polymer | 398 | 44852.1 | 1 | UniProt (P62195) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG |
| 4 | D (D) | 26S proteasome regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 5 | E (E) | Proteasome 26S subunit, ATPase 6 | polymer | 403 | 45867.0 | 1 | UniProt (A0A087X2I1) | Homo sapiens (human) | 26S proteasome regulatory subunit 10B |
| 6 | BA, F (G, g) | Proteasome subunit alpha type-6 | polymer | 245 | 27301.3 | 2 | UniProt (P60900) | Homo sapiens (human) | 27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain,Proteasome subunit alpha-1,alpha-1 |
| 7 | CA, G (H, h) | Proteasome subunit alpha type-2 | polymer | 233 | 25796.3 | 2 | UniProt (P25787) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3,Proteasome subunit alpha-2,alpha-2 |
| 8 | DA, H (I, i) | Proteasome subunit alpha type-4 | polymer | 260 | 29394.6 | 2 | UniProt (P25789) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L,Proteasome subunit alpha-3,alpha-3 |
| 9 | EA, I (J, j) | Proteasome subunit alpha type-7 | polymer | 247 | 27798.7 | 2 | UniProt (O14818) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7,Proteasome subunit alpha-4,alpha-4 |
| 10 | FA, J (L, l) | Isoform Long of Proteasome subunit alpha type-1 | polymer | 268 | 30150.3 | 2 | UniProt (P25786) | Homo sapiens (human) | 30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain,Proteasome subunit alpha-6,alpha-6 |
| 11 | GA, K (M, m) | Proteasome subunit alpha type-3 | polymer | 254 | 28338.1 | 2 | UniProt (P25788) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8,Proteasome subunit alpha-7,alpha-7 |
| 12 | HA, L (N, n) | Proteasome subunit beta type-6 | polymer | 238 | 25246.5 | 2 | UniProt (P28072) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y,Proteasome subunit beta-1,beta-1 |
| 13 | IA, M (O, o) | Proteasome subunit beta type-7 | polymer | 276 | 29869.2 | 2 | UniProt (Q99436) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z,Proteasome subunit beta-2,beta-2 |
| 14 | JA, N (P, p) | Proteasome subunit beta type-3 | polymer | 204 | 22841.7 | 2 | UniProt (P49720) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome subunit beta-3,beta-3,Proteasome theta chain |
| 15 | KA, O (Q, q) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I,Proteasome subunit beta-4,beta-4 |
| 16 | LA, P (R, r) | Proteasome subunit beta type-5 | polymer | 262 | 28379.1 | 2 | UniProt (P28074) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X,Proteasome subunit beta-5,beta-5 |
| 17 | MA, Q (S, s) | Proteasome subunit beta type-1 | polymer | 240 | 26391.2 | 2 | UniProt (P20618) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain,Proteasome subunit beta-6,beta-6 |
| 18 | NA, R (T, t) | Proteasome subunit beta type-4 | polymer | 263 | 29100.0 | 2 | UniProt (P28070) | Homo sapiens (human) | 26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3,Proteasome subunit beta-7,beta-7 |
| 19 | S (V) | 26S proteasome non-ATPase regulatory subunit 3 | polymer | 533 | 60935.3 | 1 | UniProt (O43242) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58 |
| 20 | T (W) | 26S proteasome non-ATPase regulatory subunit 12 | polymer | 456 | 52979.4 | 1 | UniProt (O00232) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55 |
| 21 | U (X) | 26S proteasome non-ATPase regulatory subunit 11 | polymer | 422 | 47526.7 | 1 | UniProt (O00231) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5 |
| 22 | V (Y) | 26S proteasome non-ATPase regulatory subunit 6 | polymer | 389 | 45592.3 | 1 | UniProt (Q15008) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A |
| 23 | W (Z) | 26S proteasome non-ATPase regulatory subunit 7 | polymer | 324 | 37086.4 | 1 | UniProt (P51665) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40 |
| 24 | X (a) | 26S proteasome non-ATPase regulatory subunit 13 | polymer | 376 | 42995.4 | 1 | UniProt (Q9UNM6) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5 |
| 25 | Y (b) | 26S proteasome non-ATPase regulatory subunit 4 | polymer | 377 | 40781.6 | 1 | UniProt (P55036) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,AF,ASF,Multiubiquitin chain-binding protein |
| 26 | Z (c) | 26S proteasome non-ATPase regulatory subunit 14 | polymer | 309 | 34488.8 | 1 | UniProt (O00487) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1 |
| 27 | AA (d) | 26S proteasome non-ATPase regulatory subunit 8 | polymer | 349 | 39536.7 | 1 | UniProt (P48556) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31 |
| 28 | OA (u) | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2 |
| 29 | PA (U) | 26S proteasome non-ATPase regulatory subunit 1 | polymer | 953 | 105958.2 | 1 | UniProt (Q99460) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112 |
| 30 | QA (e) | 26S proteasome complex subunit SEM1 | polymer | 70 | 8284.6 | 1 | UniProt (P60896) | Homo sapiens (human) | 26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein |
| 31 | RA (F) | 26S proteasome regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 32 | SA, TA (K, k) | Proteasome subunit alpha type-5 | polymer | 240 | 26304.8 | 2 | UniProt (P28066) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome subunit alpha-5,alpha-5,Proteasome zeta chain |
| 33 | UA (v) | substrate peptide | polymer | 15 | 1294.6 | 1 | Homo sapiens | ||
| 34 | CB, KB, VA (E, F, A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 3 | Chemie (ADP) | |||
| 35 | AB, WA, YA (D, B, C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 3 | Chemie (ATP) | |||
| 36 | BB, XA, ZA (D, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 37 | DB, EB, FB, HB, IB... (N, O, R, n, o...) | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide | non-polymer | 475.6 | 6 | Chemie (LDZ) | |||
| 38 | GB (c) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 47 |
| Total formula weight | 1662698.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 5795.2 | |
| All* | Total formula weight | 1668493.7 |
