9TXT
Catalytic domain of human tankyrase 2 in complex with a dual-site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 170 | 19352.9 | 2 | UniProt (Q9H2K2) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 2 | C, D (B, D) | Poly [ADP-ribose] polymerase tankyrase-2 | polymer | 48 | 5436.2 | 2 | UniProt (Q9H2K2) | Homo sapiens (human) | ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein |
| 3 | E, H (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 4 | F, I, J, L, M (A, C, B, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | G, K (A, C) | ~{N}-(2-methoxyphenyl)-4-[[2-(4-oxidanylidene-3~{H}-quinazolin-2-yl)ethyl-(thiophen-2-ylmethyl)carbamoyl]amino]benzamide | non-polymer | 553.6 | 2 | Chemie (OY6) PubChem (168654800) | |||
| 6 | N, O, P (A, C, B) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, C: 946 - 1113 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 49578.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1718.4 | |
| All* | Total formula weight | 51296.5 |
