9TP9
Crystal structure of integrin-linked kinase (ILK) in complex with Alpha-Parvin and dihydroPelitinib
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Scaffold protein ILK | polymer | 271 | 30972.0 | 1 | UniProt (Q13418) Pfam (PF07714) | Homo sapiens (human) | ILK-1,ILK-2,Inactive integrin-linked kinase,p59ILK |
| 2 | B (B) | Alpha-parvin | polymer | 127 | 14647.9 | 1 | UniProt (Q9NVD7) Pfam (PF00307) | Homo sapiens (human) | Actopaxin,CH-ILKBP,Calponin-like integrin-linked kinase-binding protein,Matrix-remodeling-associated protein 2 |
| 3 | C (A) | ~{N}-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)butanamide | non-polymer | 469.9 | 1 | Chemie (A1JW8) | |||
| 4 | D (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) PubChem (23831) | |||
| 5 | E, F, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A: 183 - 452 (UniProt: Q13418)
B: 248 - 372 (UniProt: Q9NVD7)
| PDB | External Database | Details |
|---|---|---|
| Met 182 | - | initiating methionine |
| Ser 346 | Cys 346 | conflict |
| Ser 422 | Cys 422 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 246 | - | expression tag |
| Met 247 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45619.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 894.4 | |
| All* | Total formula weight | 46514.3 |
