9TN8

cryo-EM structure of human Tryptophan 2,3-dioxygenase (TDO2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, D, C, B)	Tryptophan 2,3-dioxygenase	polymer	420	49707.3	4	UniProt (P48775)	Homo sapiens (human)	TDO,Tryptamin 2,3-dioxygenase,Tryptophan oxygenase,TO,TRPO,Tryptophan pyrrolase,Tryptophanase
2	E, F, G, H (A, D, C, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	4	Chemie (HEM)

Sequence modifications

A, D, C, B: 1 - 406 (UniProt: P48775)

PDB	External Database	Details
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	198829.3
Non-Polymers*	Number of molecules	4
	Total formula weight	2465.9
All*	Total formula weight	201295.2

*Water molecules are not included.