9TMU
Akt1 mutant in complex with the trimethyl 1,4-substituted pyrazole compound
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RAC-alpha serine/threonine-protein kinase | polymer | 445 | 51674.0 | 1 | UniProt (P31749) Pfam (PF00169) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | Protein kinase B,PKB,Protein kinase B alpha,PKB alpha,Proto-oncogene c-Akt,RAC-PK-alpha |
| 2 | B (A) | ~{N}-[2-oxidanylidene-3-[1-[[4-[3-phenyl-5-[(1,3,5-trimethylpyrazol-4-yl)methyl]pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-1~{H}-benzimidazol-5-yl]propanamide | non-polymer | 653.8 | 1 | Chemie (A1JW3) | |||
| 3 | C (A) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 2 - 446 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ala 114 | Glu 114 | engineered mutation |
| Ala 115 | Glu 115 | engineered mutation |
| Ala 116 | Glu 116 | engineered mutation |
| Thr 205 | Ser 205 | engineered mutation |
| Glu 262 | Asp 262 | engineered mutation |
| - | Glu 267 | deletion |
| Arg 268 | Lys 268 | engineered mutation |
| Asp 269 | Asn 269 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 51674.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 653.8 | |
| All* | Total formula weight | 52327.8 |
