9TLX
Crystal structure of Brugia malayi DAF-12 ligand binding domain in complex with a coactivator peptide and delta4-dafachronic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Nuclear receptor domain-containing protein | polymer | 248 | 28797.4 | 2 | UniProt (A0A4E9F2L4) Pfam (PF00104) | Brugia malayi | BMA-DAF-12,NR LBD domain-containing protein |
| 2 | B, D (B, D) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 14 | 1523.9 | 2 | UniProt (Q9UBK2) | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
| 3 | E, K (A, C) | (14beta,17alpha,25R)-3-oxocholest-4-en-26-oic acid | non-polymer | 414.6 | 2 | Chemie (DL4) PubChem (42628074) | |||
| 4 | F, L (A, C) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) PubChem (311) | |||
| 5 | G, H, I, J, M (A, C) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 6 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 643 | Chemie (HOH) |
Sequence modifications
A, C: 636 - 879 (UniProt: A0A4E9F2L4)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| His 840 | Arg 841 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60642.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1674.0 | |
| All* | Total formula weight | 62316.4 |
