9TLU

De novo designed single-chain antiparallel coiled-coil hairpin with binding site for BCL-xL, Sc-apCC-2-BCL-xL-3 in complex with BCL-xL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Bcl-2-like protein 1	polymer	153	17506.5	2	UniProt (Q07817)	Homo sapiens (human)
2	C, D (C, D)	Sc-apCC-2-BCL-xL-3	polymer	75	8663.0	2		synthetic construct

Sequence modifications

B, A: 1 - 153 (UniProt: Q07817)

PDB	External Database	Details
-	Phe 27	deletion
-	Ser 28	deletion
-	Asp 29	deletion
-	Val 30	deletion
-	Glu 31	deletion
-	Glu 32	deletion
-	Asn 33	deletion
-	Arg 34	deletion
-	Thr 35	deletion
-	Glu 36	deletion
-	Ala 37	deletion
-	Pro 38	deletion
-	Glu 39	deletion
-	Gly 40	deletion
-	Thr 41	deletion
-	Glu 42	deletion
-	Ser 43	deletion
-	Glu 44	deletion
-	Met 45	deletion
-	Glu 46	deletion
-	Thr 47	deletion
-	Pro 48	deletion
-	Ser 49	deletion
-	Ala 50	deletion
-	Ile 51	deletion
-	Asn 52	deletion
-	Gly 53	deletion
-	Asn 54	deletion
-	Pro 55	deletion
-	Ser 56	deletion
-	Trp 57	deletion
-	His 58	deletion
-	Leu 59	deletion
-	Ala 60	deletion
-	Asp 61	deletion
-	Ser 62	deletion
-	Pro 63	deletion
-	Ala 64	deletion
-	Val 65	deletion
-	Asn 66	deletion
-	Gly 67	deletion
-	Ala 68	deletion
-	Thr 69	deletion
-	Gly 70	deletion
-	His 71	deletion
-	Ser 72	deletion
-	Ser 73	deletion
-	Ser 74	deletion
-	Leu 75	deletion
-	Asp 76	deletion
-	Ala 77	deletion
-	Arg 78	deletion
-	Glu 79	deletion
-	Val 80	deletion
-	Ile 81	deletion
-	Pro 82	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	52338.9
All*	Total formula weight	52338.9

*Water molecules are not included.