9TLG
Structure of human prothrombinase with meizothrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Coagulation factor V heavy chain | polymer | 709 | 81514.6 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | |
| 2 | B (B) | Coagulation factor V light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | |
| 3 | C (H) | Activated factor Xa heavy chain | polymer | 254 | 28773.9 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) | |
| 4 | D (L) | Coagulation factor X | polymer | 110 | 12182.6 | 1 | UniProt (P00742) Pfam (PF14670) | Homo sapiens (human) | Stuart factor,Stuart-Prower factor |
| 5 | E (P) | Prothrombin | polymer | 320 | 35624.0 | 1 | UniProt (P00734) Pfam (PF09396) Pfam (PF00594) Pfam (PF00051) | Homo sapiens (human) | Coagulation factor II,Meizothrombin fragment 1.2 |
| 6 | F (Q) | Prothrombin | polymer | 259 | 29764.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Meizothrombin catalytic domain |
| 7 | G (X) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | H, J (C, E) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 9 | I (D) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G76882CO) | |||
| 10 | K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) | |||
| 11 | L (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 12 | M, N (H, Q) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) |
Sequence modifications
H: 16 - 264 (UniProt: P00742)
L: 85 - 194 (UniProt: P00742)
Q: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asn 129 | Glu 350 | engineered mutation |
| Glu 130 | Ser 351 | engineered mutation |
| Lys 132 | Thr 355 | engineered mutation |
| Asp 134 | Lys 357 | engineered mutation |
| His 166 | Asn 388 | engineered mutation |
| Met 169 | Lys 391 | engineered mutation |
| Asp 173 | Ser 395 | engineered mutation |
| Arg 175 | Ile 397 | engineered mutation |
| Ala 195 | Ser 419 | engineered mutation |
| Arg 233 | Ala 457 | engineered mutation |
| Lys 239 | Asp 463 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 85 | Thr 125 | engineered mutation |
| Arg 90 | Ser 130 | engineered mutation |
| Ala 91 | Leu 131 | engineered mutation |
| Phe 92 | Asp 132 | engineered mutation |
| Lys 101 | His 141 | engineered mutation |
| Arg 102 | Glu 142 | engineered mutation |
| Val 103 | Glu 143 | engineered mutation |
| Ser 105 | Asn 145 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 263142.2 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3643.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 307.3 | |
| All* | Total formula weight | 267092.8 |
