9TLE
Structure of human prothrombinase with prothrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Activated factor Xa heavy chain | polymer | 254 | 28773.9 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | B (L) | Coagulation factor X | polymer | 110 | 12182.6 | 1 | UniProt (P00742) Pfam (PF14670) | Homo sapiens (human) | Stuart factor,Stuart-Prower factor |
| 3 | C (A) | Coagulation factor V heavy chain | polymer | 709 | 81514.6 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | |
| 4 | D (B) | Coagulation factor V light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | |
| 5 | E (P) | Prothrombin | polymer | 579 | 65370.1 | 1 | UniProt (P00734) Pfam (PF09396) Pfam (PF00089) Pfam (PF00594) Pfam (PF00051) | Homo sapiens (human) | Coagulation factor II |
| 6 | F (C) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 7 | G, I, J (D, X, F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 8 | H (E) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1883.7 | 1 | In PDB | |||
| 9 | K (G) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G76882CO) | |||
| 10 | L (I) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 11 | M (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 12 | N (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) |
Sequence modifications
H: 16 - 264 (UniProt: P00742)
L: 85 - 194 (UniProt: P00742)
P: 1 - 579 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asn 129 | Glu 350 | engineered mutation |
| Glu 130 | Ser 351 | engineered mutation |
| Lys 132 | Thr 355 | engineered mutation |
| Asp 134 | Lys 357 | engineered mutation |
| His 166 | Asn 388 | engineered mutation |
| Met 169 | Lys 391 | engineered mutation |
| Asp 173 | Ser 395 | engineered mutation |
| Arg 175 | Ile 397 | engineered mutation |
| Ala 195 | Ser 419 | engineered mutation |
| Arg 233 | Ala 457 | engineered mutation |
| Lys 239 | Asp 463 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 85 | Thr 125 | engineered mutation |
| Arg 90 | Ser 130 | engineered mutation |
| Ala 91 | Leu 131 | engineered mutation |
| Phe 92 | Asp 132 | engineered mutation |
| Lys 101 | His 141 | engineered mutation |
| Arg 102 | Glu 142 | engineered mutation |
| Val 103 | Glu 143 | engineered mutation |
| Ser 105 | Asn 145 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 525 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 263124.2 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 7291.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 63.1 | |
| All* | Total formula weight | 270478.8 |
