9TJX
Structure of factor VII Gla domain bound to EPCR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Endothelial protein C receptor | polymer | 195 | 22214.8 | 4 | UniProt (Q9UNN8) Pfam (PF16497) | Homo sapiens (human) | Activated protein C receptor,APC receptor,Endothelial cell protein C receptor |
| 2 | E, F, G, H (L, E, F, R) | Factor VII light chain | polymer | 32 | 4190.3 | 4 | UniProt (P08709) Pfam (PF00594) | Homo sapiens | |
| 3 | I (G) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 4 | J (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | K (I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | L, M, NA, P, Q (A, F, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 7 | N, O, S, T (A, B, C, D) | PHOSPHATIDYLETHANOLAMINE | non-polymer | 734.0 | 4 | Chemie (PTY) PubChem (446872) PubChem (3330137) | |||
| 8 | R (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | BA, CA, DA, EA, FA... (E, F, R, L) | CALCIUM ION | non-polymer | 40.1 | 20 | Chemie (CA) PubChem (271) | |||
| 10 | AA, GA, HA, OA, VA... (L, E, F, R) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) PubChem (888) | |||
| 11 | PA (R) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 12 | XA, YA (L, E) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 193 (UniProt: Q9UNN8)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gln 30 | Asn 47 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 105620.2 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1727.6 | |
| Non-Polymers* | Number of molecules | 38 |
| Total formula weight | 4701.5 | |
| All* | Total formula weight | 112049.3 |
