9TFN
ERAP1 in complex with (3R,4R)-1-{3-cyano-4-methyl-6-[(4-methyloxan-4-yl)amino]pyridin-2-yl}-4-(propan-2-yl)pyrrolidine-3-carboxylic acid
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endoplasmic reticulum aminopeptidase 1 | polymer | 922 | 105371.4 | 1 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 4 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 5 | L, M (A) | (3~{R},4~{R})-1-[3-cyano-4-methyl-6-[(4-methyloxan-4-yl)amino]pyridin-2-yl]-4-propan-2-yl-pyrrolidine-3-carboxylic acid | non-polymer | 386.5 | 2 | Chemie (A1JV2) | |||
| 6 | N (A) | water | water | 18.0 | 1107 | Chemie (HOH) |
Sequence modifications
A: 1 - 941 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| Gln 70 | Asn 70 | conflict |
| Gln 154 | Asn 154 | conflict |
| Gln 414 | Asn 414 | conflict |
| Gly 486 | Cys 486 | conflict |
| - | Pro 487 | deletion |
| - | Thr 488 | deletion |
| - | Asp 489 | deletion |
| - | Gly 490 | deletion |
| - | Val 491 | deletion |
| - | Lys 492 | deletion |
| - | Gly 493 | deletion |
| - | Met 494 | deletion |
| - | Asp 495 | deletion |
| - | Gly 496 | deletion |
| - | Phe 497 | deletion |
| - | Cys 498 | deletion |
| - | Ser 499 | deletion |
| - | Arg 500 | deletion |
| - | Ser 501 | deletion |
| - | Gln 502 | deletion |
| - | His 503 | deletion |
| - | Ser 504 | deletion |
| - | Ser 505 | deletion |
| - | Ser 506 | deletion |
| - | Ser 507 | deletion |
| - | Ser 508 | deletion |
| - | His 509 | deletion |
| - | Trp 510 | deletion |
| - | His 511 | deletion |
| Ser 512 | Gln 512 | conflict |
| Gly 513 | Glu 513 | conflict |
| Arg 528 | Lys 528 | variant |
| Gln 760 | Asn 760 | conflict |
| Glu 942 | - | expression tag |
| Asn 943 | - | expression tag |
| Leu 944 | - | expression tag |
| Tyr 945 | - | expression tag |
| Phe 946 | - | expression tag |
| Gln 947 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 105371.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1462.8 | |
| All* | Total formula weight | 106834.2 |
