9TE8

Cryo-EM structure of C5-CVFBb (state 1.1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Complement C5 beta chain	polymer	659	73930.2	1	UniProt (P01031) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703)	Homo sapiens (human)	Complement C5
2	B (C)	Complement C5 alpha chain	polymer	999	112635.0	1	UniProt (P01031) Pfam (PF07677) Pfam (PF01759) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309)	Homo sapiens (human)	Complement C5
3	C (B)	Cobra venom factor alpha chain	polymer	627	69582.0	1	UniProt (Q91132)	Naja kaouthia (monocled cobra)	Cobra venom factor
4	D (D)	Cobra venom factor gamma chain	polymer	252	28418.6	1	UniProt (Q91132)	Naja kaouthia (monocled cobra)	Cobra venom factor
5	E (E)	Cobra venom factor beta chain	polymer	379	43626.5	1	UniProt (Q91132)	Naja kaouthia (monocled cobra)	Cobra venom factor
6	F (J)	Complement factor B	polymer	505	57042.1	1	UniProt (P00751) Pfam (PF00092) Pfam (PF00089)	Homo sapiens (human)	C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B
7	G (F)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
8	H (J)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
9	I, J (E, J)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

J: 260 - 764 (UniProt: P00751)

PDB	External Database	Details
Gly 279	Asp 279	engineered mutation
Ala 699	Ser 699	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	385234.3
Branched	Number of molecules	1
	Total formula weight	910.8
Non-Polymers*	Number of molecules	1
	Total formula weight	24.3
All*	Total formula weight	386169.5

*Water molecules are not included.