9TE2
Cryo-EM structure of C5*-CVFBb (state 2.3)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Complement C5 beta chain | polymer | 659 | 73930.2 | 1 | UniProt (P01031) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703) | Homo sapiens (human) | Complement C5 |
| 2 | B (C) | Complement C5 alpha chain | polymer | 999 | 112635.0 | 1 | UniProt (P01031) Pfam (PF07677) Pfam (PF01759) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) | Homo sapiens (human) | Complement C5 |
| 3 | C (B) | Cobra venom factor alpha chain | polymer | 627 | 69582.0 | 1 | UniProt (Q91132) | Naja kaouthia (monocled cobra) | Cobra venom factor |
| 4 | D (D) | Cobra venom factor gamma chain | polymer | 252 | 28418.6 | 1 | UniProt (Q91132) | Naja kaouthia (monocled cobra) | Cobra venom factor |
| 5 | E (E) | Cobra venom factor beta chain | polymer | 379 | 43626.5 | 1 | UniProt (Q91132) | Naja kaouthia (monocled cobra) | Cobra venom factor |
| 6 | F (J) | Complement factor B | polymer | 764 | 85567.8 | 1 | UniProt (P00751) Pfam (PF00084) Pfam (PF00092) Pfam (PF00089) | Homo sapiens (human) | C3/C5 convertase,Glycine-rich beta glycoprotein,GBG,PBF2,Properdin factor B |
| 7 | G (J) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 8 | H (J) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
J: 1 - 764 (UniProt: P00751)
| PDB | External Database | Details |
|---|---|---|
| Gly 279 | Asp 279 | engineered mutation |
| Ala 699 | Ser 699 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 413760.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 413784.4 |
