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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9TAX

Structure of the human inner kinetochore CCAN bound to a mono-CENP-A nucleosome

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(H)		Centromere protein Hpolymer24728520.91UniProt (Q9H3R5)Homo sapiens (human)
2B
(I)		Centromere protein Ipolymer76287615.01UniProt (A0A8C8KX99)Homo sapiens (human)
3C
(K)		Centromere protein Kpolymer26931696.11UniProt (Q9BS16)Homo sapiens (human)
4D
(M)		Centromere protein Mpolymer18019761.91UniProt (Q9NSP4)Homo sapiens (human)
5E
(L)		Centromere protein Lpolymer34839364.01UniProt (Q8N0S6)Homo sapiens (human)CENP-L,Interphase centromere complex protein 33
6F
(N)		Isoform 3 of Centromere protein Npolymer34740541.61UniProt (Q96H22)Homo sapiens (human)CENP-N,Interphase centromere complex protein 32
7G
(O)		Centromere protein Opolymer30033830.61UniProt (Q9BU64)Homo sapiens (human)
8H
(P)		Centromere protein Ppolymer28833210.91UniProt (Q6IPU0)Homo sapiens (human)
9I
(Q)		Centromere protein Qpolymer21524634.51UniProt (Q7L2Z9)Homo sapiens (human)CENP-Q
10J
(U)		Centromere protein Upolymer21124484.91UniProt (Q71F23)Homo sapiens (human)CENP-U,Centromere protein of 50 kDa,CENP-50,Interphase centromere complex protein 24,KSHV latent nuclear antigen-interacting protein 1,MLF1-interacting protein,Polo-box-interacting protein 1
11K
(R)		Centromere protein Rpolymer17720228.31UniProt (Q13352)Homo sapiens (human)
12L
(T)		Centromere protein Tpolymer77784067.71UniProt (Q96BT3)Homo sapiens (human)CENP-T,Interphase centromere complex protein 22
13M
(W)		Centromere protein Wpolymer8810087.21UniProt (Q5EE01)Homo sapiens (human)
14N
(S)		Centromere protein Spolymer13815917.91UniProt (Q8N2Z9)Homo sapiens (human)
15O
(X)		Centromere protein Xpolymer818972.41UniProt (A8MT69)Homo sapiens (human)
16P
(V)		DNA (199-MER)polymer21265387.71Homo sapiens
17Q
(Y)		DNA (199-MER)polymer21265508.81Homo sapiens
18R, S
(a, b)		Centromere protein Cpolymer77586473.12UniProt (Q03188)Homo sapiens (human)
19T, X
(c, g)		Histone H3-like centromeric protein Apolymer14016023.62UniProt (P49450)Homo sapiens (human)
20U, Y
(d, h)		Histone H4polymer10311394.42UniProt (P62805)Homo sapiens (human)
21V, Z
(e, i)		Histone H2A type 1-Cpolymer15316666.32UniProt (Q93077)Homo sapiens (human)H2A-clustered histone 6,Histone H2A/l
22AA, W
(f, j)		Histone H2B type 1-C/E/F/G/Ipolymer12613937.22UniProt (P62807)Homo sapiens (human)Histone H2B.1 A,Histone H2B.a,H2B/a,Histone H2B.g,H2B/g,Histone H2B.h,H2B/h,Histone H2B.k,H2B/k,Histone H2B.l,H2B/l
Sequence modifications
I: 1 - 756 (UniProt: A0A8C8KX99)
PDBExternal DatabaseDetails
Glu 699-insertion
Ser 700-insertion
Pro 701-insertion
Glu 702-insertion
Glu 703-insertion
Arg 704-insertion
Thr 705-insertion
Val 706-insertion
Asn 707-insertion
Val 708-insertion
Ser 709-insertion
Ser 710-insertion
Ile 711-insertion
Arg 712-insertion
Glu 757-expression tag
Asn 758-expression tag
Leu 759-expression tag
Tyr 760-expression tag
Phe 761-expression tag
Gln 762-expression tag
L: 1 - 344 (UniProt: Q8N0S6)
PDBExternal DatabaseDetails
Gly -3-expression tag
Pro -2-expression tag
Leu -1-expression tag
Gly 0-expression tag
N: 1 - 315 (UniProt: Q96H22)
PDBExternal DatabaseDetails
Lys 288Glu 288conflict
Gly 313Ala 313conflict
Ile 314Leu 314conflict
Ala 315Val 315conflict
Asp 316-expression tag
Ala 317-expression tag
Pro 318-expression tag
Leu 319-expression tag
Ser 320-expression tag
Pro 321-expression tag
Leu 322-expression tag
Leu 323-expression tag
Thr 324-expression tag
Cys 325-expression tag
Ile 326-expression tag
Pro 327-expression tag
Asn 328-expression tag
Lys 329-expression tag
Arg 330-expression tag
Met 331-expression tag
Asn 332-expression tag
Tyr 333-expression tag
Phe 334-expression tag
Lys 335-expression tag
Ile 336-expression tag
Arg 337-expression tag
Asp 338-expression tag
Lys 339-expression tag
Ser 340-expression tag
Asp 341-expression tag
Leu 342-expression tag
Glu 343-expression tag
Val 344-expression tag
Leu 345-expression tag
Phe 346-expression tag
Gln 347-expression tag
Q: 55 - 268 (UniProt: Q7L2Z9)
PDBExternal DatabaseDetails
Met 54-initiating methionine
U: 243 - 418 (UniProt: Q71F23)
PDBExternal DatabaseDetails
Glu 419-expression tag
Asn 420-expression tag
Leu 421-expression tag
Tyr 422-expression tag
Phe 423-expression tag
Gln 424-expression tag
Ser 425-expression tag
Trp 426-expression tag
Ser 427-expression tag
His 428-expression tag
Pro 429-expression tag
Gln 430-expression tag
Phe 431-expression tag
Glu 432-expression tag
Lys 433-expression tag
Gly 434-expression tag
Gly 435-expression tag
Gly 436-expression tag
Ser 437-expression tag
Gly 438-expression tag
Gly 439-expression tag
Gly 440-expression tag
Ser 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Gly 444-expression tag
Ser 445-expression tag
Trp 446-expression tag
Ser 447-expression tag
His 448-expression tag
Pro 449-expression tag
Gln 450-expression tag
Phe 451-expression tag
Glu 452-expression tag
Lys 453-expression tag
T: 1 - 561 (UniProt: Q96BT3)
PDBExternal DatabaseDetails
Met -215-initiating methionine
Ser -214-expression tag
Tyr -213-expression tag
Tyr -212-expression tag
His -211-expression tag
His -210-expression tag
His -209-expression tag
His -208-expression tag
His -207-expression tag
His -206-expression tag
Asp -205-expression tag
Tyr -204-expression tag
Asp -203-expression tag
Ile -202-expression tag
Pro -201-expression tag
Thr -200-expression tag
Thr -199-expression tag
Glu -198-expression tag
Asn -197-expression tag
Leu -196-expression tag
Tyr -195-expression tag
Phe -194-expression tag
Gln -193-expression tag
Gly -192-expression tag
Met -191-expression tag
Asp -190-expression tag
Lys -189-expression tag
Asp -188-expression tag
Cys -187-expression tag
Glu -186-expression tag
Met -185-expression tag
Lys -184-expression tag
Arg -183-expression tag
Thr -182-expression tag
Thr -181-expression tag
Leu -180-expression tag
Asp -179-expression tag
Ser -178-expression tag
Pro -177-expression tag
Leu -176-expression tag
Gly -175-expression tag
Lys -174-expression tag
Leu -173-expression tag
Glu -172-expression tag
Leu -171-expression tag
Ser -170-expression tag
Gly -169-expression tag
Cys -168-expression tag
Glu -167-expression tag
Gln -166-expression tag
Gly -165-expression tag
Leu -164-expression tag
His -163-expression tag
Arg -162-expression tag
Ile -161-expression tag
Ile -160-expression tag
Phe -159-expression tag
Leu -158-expression tag
Gly -157-expression tag
Lys -156-expression tag
Gly -155-expression tag
Thr -154-expression tag
Ser -153-expression tag
Ala -152-expression tag
Ala -151-expression tag
Asp -150-expression tag
Ala -149-expression tag
Val -148-expression tag
Glu -147-expression tag
Val -146-expression tag
Pro -145-expression tag
Ala -144-expression tag
Pro -143-expression tag
Ala -142-expression tag
Ala -141-expression tag
Val -140-expression tag
Leu -139-expression tag
Gly -138-expression tag
Gly -137-expression tag
Pro -136-expression tag
Glu -135-expression tag
Pro -134-expression tag
Leu -133-expression tag
Met -132-expression tag
Gln -131-expression tag
Ala -130-expression tag
Thr -129-expression tag
Ala -128-expression tag
Trp -127-expression tag
Leu -126-expression tag
Asn -125-expression tag
Ala -124-expression tag
Tyr -123-expression tag
Phe -122-expression tag
His -121-expression tag
Gln -120-expression tag
Pro -119-expression tag
Glu -118-expression tag
Ala -117-expression tag
Ile -116-expression tag
Glu -115-expression tag
Glu -114-expression tag
Phe -113-expression tag
Pro -112-expression tag
Val -111-expression tag
Pro -110-expression tag
Ala -109-expression tag
Leu -108-expression tag
His -107-expression tag
His -106-expression tag
Pro -105-expression tag
Val -104-expression tag
Phe -103-expression tag
Gln -102-expression tag
Gln -101-expression tag
Glu -100-expression tag
Ser -99-expression tag
Phe -98-expression tag
Thr -97-expression tag
Arg -96-expression tag
Gln -95-expression tag
Val -94-expression tag
Leu -93-expression tag
Trp -92-expression tag
Lys -91-expression tag
Leu -90-expression tag
Leu -89-expression tag
Lys -88-expression tag
Val -87-expression tag
Val -86-expression tag
Lys -85-expression tag
Phe -84-expression tag
Gly -83-expression tag
Glu -82-expression tag
Val -81-expression tag
Ile -80-expression tag
Ser -79-expression tag
Tyr -78-expression tag
Ser -77-expression tag
His -76-expression tag
Leu -75-expression tag
Ala -74-expression tag
Ala -73-expression tag
Leu -72-expression tag
Ala -71-expression tag
Gly -70-expression tag
Asn -69-expression tag
Pro -68-expression tag
Ala -67-expression tag
Ala -66-expression tag
Thr -65-expression tag
Ala -64-expression tag
Ala -63-expression tag
Val -62-expression tag
Lys -61-expression tag
Thr -60-expression tag
Ala -59-expression tag
Leu -58-expression tag
Ser -57-expression tag
Gly -56-expression tag
Asn -55-expression tag
Pro -54-expression tag
Val -53-expression tag
Pro -52-expression tag
Ile -51-expression tag
Leu -50-expression tag
Ile -49-expression tag
Pro -48-expression tag
Cys -47-expression tag
His -46-expression tag
Arg -45-expression tag
Val -44-expression tag
Val -43-expression tag
Gln -42-expression tag
Gly -41-expression tag
Asp -40-expression tag
Leu -39-expression tag
Asp -38-expression tag
Val -37-expression tag
Gly -36-expression tag
Gly -35-expression tag
Tyr -34-expression tag
Glu -33-expression tag
Gly -32-expression tag
Gly -31-expression tag
Leu -30-expression tag
Ala -29-expression tag
Val -28-expression tag
Lys -27-expression tag
Glu -26-expression tag
Trp -25-expression tag
Leu -24-expression tag
Leu -23-expression tag
Ala -22-expression tag
His -21-expression tag
Glu -20-expression tag
Gly -19-expression tag
His -18-expression tag
Arg -17-expression tag
Leu -16-expression tag
Gly -15-expression tag
Lys -14-expression tag
Pro -13-expression tag
Gly -12-expression tag
Leu -11-expression tag
Gly -10-expression tag
Ser -9-expression tag
Asp -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
a, b: 1 - 545 (UniProt: Q03188)
PDBExternal DatabaseDetails
Asp 546-expression tag
Leu 547-expression tag
Glu 548-expression tag
Val 549-expression tag
Leu 550-expression tag
Phe 551-expression tag
Gln 552-expression tag
Gly 553-expression tag
Pro 554-expression tag
Leu 555-expression tag
Gly 556-expression tag
Met 557-expression tag
Asp 558-expression tag
Lys 559-expression tag
Asp 560-expression tag
Cys 561-expression tag
Glu 562-expression tag
Met 563-expression tag
Lys 564-expression tag
Arg 565-expression tag
Thr 566-expression tag
Thr 567-expression tag
Leu 568-expression tag
Asp 569-expression tag
Ser 570-expression tag
Pro 571-expression tag
Leu 572-expression tag
Gly 573-expression tag
Lys 574-expression tag
Leu 575-expression tag
Glu 576-expression tag
Leu 577-expression tag
Ser 578-expression tag
Gly 579-expression tag
Cys 580-expression tag
Glu 581-expression tag
Gln 582-expression tag
Gly 583-expression tag
Leu 584-expression tag
His 585-expression tag
Arg 586-expression tag
Ile 587-expression tag
Ile 588-expression tag
Phe 589-expression tag
Leu 590-expression tag
Gly 591-expression tag
Lys 592-expression tag
Gly 593-expression tag
Thr 594-expression tag
Ser 595-expression tag
Ala 596-expression tag
Ala 597-expression tag
Asp 598-expression tag
Ala 599-expression tag
Val 600-expression tag
Glu 601-expression tag
Val 602-expression tag
Pro 603-expression tag
Ala 604-expression tag
Pro 605-expression tag
Ala 606-expression tag
Ala 607-expression tag
Val 608-expression tag
Leu 609-expression tag
Gly 610-expression tag
Gly 611-expression tag
Pro 612-expression tag
Glu 613-expression tag
Pro 614-expression tag
Leu 615-expression tag
Met 616-expression tag
Gln 617-expression tag
Ala 618-expression tag
Thr 619-expression tag
Ala 620-expression tag
Trp 621-expression tag
Leu 622-expression tag
Asn 623-expression tag
Ala 624-expression tag
Tyr 625-expression tag
Phe 626-expression tag
His 627-expression tag
Gln 628-expression tag
Pro 629-expression tag
Glu 630-expression tag
Ala 631-expression tag
Ile 632-expression tag
Glu 633-expression tag
Glu 634-expression tag
Phe 635-expression tag
Pro 636-expression tag
Val 637-expression tag
Pro 638-expression tag
Ala 639-expression tag
Leu 640-expression tag
His 641-expression tag
His 642-expression tag
Pro 643-expression tag
Val 644-expression tag
Phe 645-expression tag
Gln 646-expression tag
Gln 647-expression tag
Glu 648-expression tag
Ser 649-expression tag
Phe 650-expression tag
Thr 651-expression tag
Arg 652-expression tag
Gln 653-expression tag
Val 654-expression tag
Leu 655-expression tag
Trp 656-expression tag
Lys 657-expression tag
Leu 658-expression tag
Leu 659-expression tag
Lys 660-expression tag
Val 661-expression tag
Val 662-expression tag
Lys 663-expression tag
Phe 664-expression tag
Gly 665-expression tag
Glu 666-expression tag
Val 667-expression tag
Ile 668-expression tag
Ser 669-expression tag
Tyr 670-expression tag
Ser 671-expression tag
His 672-expression tag
Leu 673-expression tag
Ala 674-expression tag
Ala 675-expression tag
Leu 676-expression tag
Ala 677-expression tag
Gly 678-expression tag
Asn 679-expression tag
Pro 680-expression tag
Ala 681-expression tag
Ala 682-expression tag
Thr 683-expression tag
Ala 684-expression tag
Ala 685-expression tag
Val 686-expression tag
Lys 687-expression tag
Thr 688-expression tag
Ala 689-expression tag
Leu 690-expression tag
Ser 691-expression tag
Gly 692-expression tag
Asn 693-expression tag
Pro 694-expression tag
Val 695-expression tag
Pro 696-expression tag
Ile 697-expression tag
Leu 698-expression tag
Ile 699-expression tag
Pro 700-expression tag
Cys 701-expression tag
His 702-expression tag
Arg 703-expression tag
Val 704-expression tag
Val 705-expression tag
Gln 706-expression tag
Gly 707-expression tag
Asp 708-expression tag
Leu 709-expression tag
Asp 710-expression tag
Val 711-expression tag
Gly 712-expression tag
Gly 713-expression tag
Tyr 714-expression tag
Glu 715-expression tag
Gly 716-expression tag
Gly 717-expression tag
Leu 718-expression tag
Ala 719-expression tag
Val 720-expression tag
Lys 721-expression tag
Glu 722-expression tag
Trp 723-expression tag
Leu 724-expression tag
Leu 725-expression tag
Ala 726-expression tag
His 727-expression tag
Glu 728-expression tag
Gly 729-expression tag
His 730-expression tag
Arg 731-expression tag
Leu 732-expression tag
Gly 733-expression tag
Lys 734-expression tag
Pro 735-expression tag
Gly 736-expression tag
Leu 737-expression tag
Gly 738-expression tag
Glu 739-expression tag
Asn 740-expression tag
Leu 741-expression tag
Tyr 742-expression tag
Phe 743-expression tag
Gln 744-expression tag
Ser 745-expression tag
Ser 746-expression tag
Ala 747-expression tag
Trp 748-expression tag
Ser 749-expression tag
His 750-expression tag
Pro 751-expression tag
Gln 752-expression tag
Phe 753-expression tag
Glu 754-expression tag
Lys 755-expression tag
Gly 756-expression tag
Gly 757-expression tag
Gly 758-expression tag
Ser 759-expression tag
Gly 760-expression tag
Gly 761-expression tag
Gly 762-expression tag
Ser 763-expression tag
Gly 764-expression tag
Gly 765-expression tag
Ser 766-expression tag
Ala 767-expression tag
Trp 768-expression tag
Ser 769-expression tag
His 770-expression tag
Pro 771-expression tag
Gln 772-expression tag
Phe 773-expression tag
Glu 774-expression tag
Lys 775-expression tag
e, i: 0 - 129 (UniProt: Q93077)
PDBExternal DatabaseDetails
Met -23-initiating methionine
Gly -22-expression tag
Ser -21-expression tag
Ser -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
Ser -13-expression tag
Pro -12-expression tag
Gly -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Arg -2-expression tag
Gly -1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains27
Total formula weight922820.1
All*Total formula weight922820.1
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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