9T9X

Human fumarylacetoacetate hydrolase (FAH) in complex with Acetoacetate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Fumarylacetoacetase	polymer	441	49088.1	2	UniProt (P16930)	Homo sapiens (human)	FAA,Beta-diketonase,Fumarylacetoacetate hydrolase
2	C, O (A, B)	ACETOACETIC ACID	non-polymer		102.1	2	Chemie (AAE)
3	D, E, H, I, P... (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	8	Chemie (PEG) PubChem (8117)
4	F, G, S, U, V... (A, B)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL) PubChem (753)
5	AA, BA, CA, DA, EA... (B, A)	CALCIUM ION	non-polymer		40.1	12	Chemie (CA) PubChem (271)
6	T (B)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS) PubChem (679)
7	FA (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL) PubChem (312)
8	GA, HA (A, B)	water	water		18.0	851	Chemie (HOH)

Sequence modifications

A, B: 1 - 419 (UniProt: P16930)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
His -6	-	expression tag
Ile -5	-	expression tag
Glu -4	-	expression tag
Gly -3	-	expression tag
Arg -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	98176.1
Non-Polymers*	Number of molecules	30
	Total formula weight	2200.2
All*	Total formula weight	100376.4

*Water molecules are not included.