9T8C
Cryo-EM structure of cariprazine-bound D3 dopamine receptor with mini-Go
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(3) dopamine receptor,Dopamine 3 receptor | polymer | 573 | 62837.4 | 1 | UniProt (A0A2R9AV93) | Homo sapiens (human) | Dopamine D3 receptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 226 | 25248.9 | 1 | UniProt (P09471) | Homo sapiens (human) | |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 366 | 39728.4 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 5 | E (S) | scFv16 | polymer | 256 | 27340.5 | 1 | Mus musculus | ||
| 6 | F (R) | 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea | non-polymer | 427.4 | 1 | Chemie (7RU) |
Sequence modifications
R: 1 - 400 (UniProt: A0A2R9AV93)
R: 416 - 573 (PDB: 9T8C)
A: 2 - 55 (UniProt: P09471)
A: 64 - 226 (UniProt: P09471)
B: 0 - 339 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Ser 3 | Pro 3 | conflict |
| Gly 401 | - | linker |
| Ser 402 | - | linker |
| Ser 403 | - | linker |
| Gly 404 | - | linker |
| Gly 405 | - | linker |
| Gly 406 | - | linker |
| Gly 407 | - | linker |
| Ser 408 | - | linker |
| Gly 409 | - | linker |
| Gly 410 | - | linker |
| Gly 411 | - | linker |
| Gly 412 | - | linker |
| Ser 413 | - | linker |
| Ser 414 | - | linker |
| Gly 415 | - | linker |
A: 2 - 55 (UniProt: P09471)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Val 3 | Leu 5 | engineered mutation |
| Asp 7 | Glu 9 | engineered mutation |
| Lys 8 | Arg 10 | engineered mutation |
| Ala 11 | Leu 13 | engineered mutation |
| Met 16 | Ala 18 | engineered mutation |
| Asp 40 | Gly 42 | engineered mutation |
| Asn 41 | Glu 43 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 56 | - | linker |
| Gly 57 | - | linker |
| Ser 58 | - | linker |
| Gly 59 | - | linker |
| Gly 60 | - | linker |
| Ser 61 | - | linker |
| Gly 62 | - | linker |
| Gly 63 | - | linker |
| Asp 109 | Ala 227 | conflict |
| Asp 112 | Gly 230 | conflict |
| - | Asp 232 | deletion |
| - | Gln 233 | deletion |
| - | Val 234 | deletion |
| - | Leu 235 | deletion |
| - | His 236 | deletion |
| - | Glu 237 | deletion |
| - | Asp 238 | deletion |
| - | Glu 239 | deletion |
| - | Thr 240 | deletion |
| - | Thr 241 | deletion |
| Ala 204 | Ile 332 | engineered mutation |
| Ile 207 | Val 335 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 340 | - | expression tag |
| Ser 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Gly 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Gly 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Ser 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Val 355 | - | expression tag |
| Ser 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Trp 358 | - | expression tag |
| Arg 359 | - | expression tag |
| Leu 360 | - | expression tag |
| Phe 361 | - | expression tag |
| Lys 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Ile 364 | - | expression tag |
| Ser 365 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 163016.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 427.4 | |
| All* | Total formula weight | 163443.8 |
