9T7V
Structure of LRRC58-EloB/C-CDO1 in complex with NEDD8-CUL5-RBX2-ARIH2-Ub
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cysteine dioxygenase type 1 | polymer | 200 | 22867.6 | 1 | UniProt (Q16878) | Homo sapiens (human) | Cysteine dioxygenase type I,CDO,CDO-I |
| 2 | B (R) | RING-box protein 2 | polymer | 109 | 12280.9 | 1 | UniProt (Q9UBF6) | Homo sapiens (human) | Rbx2,CKII beta-binding protein 1,CKBBP1,RING finger protein 7,Regulator of cullins 2,Sensitive to apoptosis gene protein |
| 3 | C (U) | Ubiquitin | polymer | 75 | 8519.8 | 1 | UniProt (P0CG48) | Homo sapiens (human) | |
| 4 | D (O) | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 5 | E (N) | NEDD8 | polymer | 76 | 8574.0 | 1 | UniProt (Q15843) | Homo sapiens (human) | Neddylin,Neural precursor cell expressed developmentally down-regulated protein 8,NEDD-8,Ubiquitin-like protein Nedd8 |
| 6 | F (C) | Cullin-5 | polymer | 780 | 91085.3 | 1 | UniProt (Q93034) | Homo sapiens (human) | CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1 |
| 7 | G (H) | E3 ubiquitin-protein ligase ARIH2 | polymer | 493 | 57735.7 | 1 | UniProt (O95376) | Homo sapiens (human) | ARI-2,Protein ariadne-2 homolog,Triad1 protein |
| 8 | H (I) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 9 | I (B) | Leucine-rich repeat-containing protein 58 | polymer | 371 | 40626.6 | 1 | UniProt (Q96CX6) | Homo sapiens (human) | |
| 10 | J (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) PubChem (29936) | |||
| 11 | K (A) | 5-azanylpentan-2-one | non-polymer | 101.1 | 1 | Chemie (SY8) PubChem (13593306) | |||
| 12 | L, M, N, O, P... (R, H, B) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) |
Sequence modifications
A: 1 - 200 (UniProt: Q16878)
H: 1 - 493 (UniProt: O95376)
| PDB | External Database | Details |
|---|---|---|
| Cys 8 | Lys 8 | engineered mutation |
| Ala 76 | Cys 76 | engineered mutation |
| Ser 93 | Cys 93 | engineered mutation |
| Ala 130 | Cys 130 | engineered mutation |
| Val 137 | Ile 137 | conflict |
| Ser 164 | Cys 164 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 381 | Leu 381 | engineered mutation |
| Ala 382 | Glu 382 | engineered mutation |
| Ala 455 | Glu 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 267322.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 680.3 | |
| All* | Total formula weight | 268003.1 |
