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9T43

Human PRMT5:MEP50 in complex with AZD3470

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Protein arginine N-methyltransferase 5, N-terminally processedpolymer63772766.71UniProt (O14744)Homo sapiens (human)
2B
(B)
Methylosome protein WDR77polymer34236757.21UniProt (Q9BQA1)Homo sapiens (human)Androgen receptor cofactor p44,Methylosome protein 50,MEP-50,WD repeat-containing protein 77,p44/Mep50
3C
(A)
(3~{S})-2-[(5-azanyl-6-fluoranyl-1~{H}-pyrrolo[3,2-b]pyridin-2-yl)methyl]-1'-but-2-ynyl-6-fluoranyl-spiro[isoindole-3,3'-pyrrolidine]-1,2'-dionenon-polymer435.41Chemie (A1JTI)
4D
(A)
5'-DEOXY-5'-METHYLTHIOADENOSINEnon-polymer297.31Chemie (MTA)
PubChem (439176)
5E
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
6F, G
(A, B)
waterwater18.059Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight109523.9
Non-Polymers*Number of molecules3
Total formula weight828.8
All*Total formula weight110352.7
*Water molecules are not included.

254917

PDB entries from 2026-06-10

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