9T2C
Human Single Domain TCR-like Antibody A10 in complex with NY-ESO-1(C165V):HLA-A0201
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | MHC class I antigen | polymer | 276 | 31985.4 | 2 | UniProt (A5I8L1) | Homo sapiens (human) | |
| 2 | B, E (B, E) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Cancer/testis antigen 1 | polymer | 9 | 1090.3 | 2 | UniProt (P78358) | Homo sapiens | Autoimmunogenic cancer/testis antigen NY-ESO-1,Cancer/testis antigen 6.1,CT6.1,L antigen family member 2,LAGE-2 |
| 4 | G, H (G, H) | A10 single-domain antibody | polymer | 147 | 16096.6 | 2 | Homo sapiens (human) | ||
| 5 | I, J (A, D) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 6 | K, L (A, D) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 275 (UniProt: A5I8L1)
B, E: 1 - 99 (UniProt: P61769)
C, F: 1 - 9 (UniProt: P78358)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Val 9 | Cys 165 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 122103.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 70.9 | |
| All* | Total formula weight | 122174.2 |
