9T0B
Crystal structure of D1228V c-MET bound by sitravatinib.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 309 | 34826.4 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | B (A) | Sitravatinib | non-polymer | 629.7 | 1 | Chemie (A1JSO) | |||
| 3 | C (A) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34826.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 629.7 | |
| All* | Total formula weight | 35456.0 |
