9SZV

Co-chaperone Bag1-bound human 26S proteasome in SBAG1.3 state

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I (G, g)	Proteasome subunit alpha type-6	polymer	246	27432.5	2	UniProt (P60900)	Homo sapiens (human)	27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
2	B, J (H, h)	Proteasome subunit alpha type-2	polymer	234	25927.5	2	UniProt (P25787)	Homo sapiens (human)	Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
3	C, K (I, i)	Proteasome subunit alpha type-4	polymer	261	29525.8	2	UniProt (P25789)	Homo sapiens (human)	Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
4	D, L (J, j)	Proteasome subunit alpha type-7	polymer	248	27929.9	2	UniProt (O14818)	Homo sapiens (human)	Proteasome subunit RC6-1,Proteasome subunit XAPC7
5	E, H (L, l)	Isoform Long of Proteasome subunit alpha type-1	polymer	269	30281.5	2	UniProt (P25786)	Homo sapiens (human)	30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain,Proteasome subunit alpha-6,alpha-6
6	F, N (M, m)	Proteasome subunit alpha type-3	polymer	255	28469.3	2	UniProt (P25788)	Homo sapiens (human)	Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
7	G, M (K, k)	Proteasome subunit alpha type-5	polymer	241	26436.0	2	UniProt (P28066)	Homo sapiens (human)	Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
8	O, V (n, N)	Proteasome subunit beta type-6	polymer	239	25377.7	2	UniProt (P28072)	Homo sapiens (human)	Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
9	P, W (o, O)	Proteasome subunit beta type-7	polymer	277	30000.4	2	UniProt (Q99436)	Homo sapiens (human)	Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
10	Q, Y (p, P)	Proteasome subunit beta type-3	polymer	205	22972.9	2	UniProt (P49720)	Homo sapiens (human)	Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
11	R, X (q, Q)	Proteasome subunit beta type-2	polymer	201	22864.3	2	UniProt (P49721)	Homo sapiens (human)	Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
12	S, Z (r, R)	Proteasome subunit beta type-5	polymer	263	28510.2	2	UniProt (P28074)	Homo sapiens (human)	Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
13	AA, T (s, S)	Proteasome subunit beta type-1	polymer	241	26522.4	2	UniProt (P20618)	Homo sapiens (human)	Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
14	BA, U (t, T)	Proteasome subunit beta type-4	polymer	264	29231.2	2	UniProt (P28070)	Homo sapiens (human)	26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
15	CA (f)	26S proteasome non-ATPase regulatory subunit 2	polymer	908	100313.6	1	UniProt (Q13200)	Homo sapiens (human)	26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2
16	DA (x)	BAG family molecular chaperone regulator 1	polymer	230	26024.7	1	UniProt (Q99933)	Homo sapiens (human)	BAG-1,Bcl-2-associated athanogene 1
17	EA (a)	26S proteasome non-ATPase regulatory subunit 13	polymer	376	42995.4	1	UniProt (Q9UNM6)	Homo sapiens (human)	26S proteasome regulatory subunit RPN9,26S proteasome regulatory subunit S11,26S proteasome regulatory subunit p40.5
18	FA (b)	26S proteasome non-ATPase regulatory subunit 4	polymer	377	40781.6	1	UniProt (P55036)	Homo sapiens (human)	26S proteasome regulatory subunit RPN10,26S proteasome regulatory subunit S5A,Antisecretory factor 1,ASF,Multiubiquitin chain-binding protein
19	GA (c)	26S proteasome non-ATPase regulatory subunit 14	polymer	310	34620.0	1	UniProt (O00487)	Homo sapiens (human)	26S proteasome regulatory subunit RPN11,26S proteasome-associated PAD1 homolog 1
20	HA (d)	26S proteasome non-ATPase regulatory subunit 8	polymer	350	39667.9	1	UniProt (P48556)	Homo sapiens (human)	26S proteasome regulatory subunit RPN12,26S proteasome regulatory subunit S14,p31
21	IA (e)	26S proteasome complex subunit SEM1	polymer	70	8284.6	1	UniProt (P60896)	Homo sapiens (human)	26S proteasome complex subunit DSS1,Deleted in split hand/split foot protein 1,Split hand/foot deleted protein 1,Split hand/foot malformation type 1 protein
22	JA (U)	26S proteasome non-ATPase regulatory subunit 1	polymer	953	105958.2	1	UniProt (Q99460)	Homo sapiens (human)	26S proteasome regulatory subunit RPN2,26S proteasome regulatory subunit S1,26S proteasome subunit p112
23	KA (V)	26S proteasome non-ATPase regulatory subunit 3	polymer	534	61066.5	1	UniProt (O43242)	Homo sapiens (human)	26S proteasome regulatory subunit RPN3,26S proteasome regulatory subunit S3,Proteasome subunit p58
24	LA (X)	26S proteasome non-ATPase regulatory subunit 11	polymer	422	47526.7	1	UniProt (O00231)	Homo sapiens (human)	26S proteasome regulatory subunit RPN6,26S proteasome regulatory subunit S9,26S proteasome regulatory subunit p44.5
25	MA (Y)	26S proteasome non-ATPase regulatory subunit 6	polymer	389	45592.3	1	UniProt (Q15008)	Homo sapiens (human)	26S proteasome regulatory subunit RPN7,26S proteasome regulatory subunit S10,Breast cancer-associated protein SGA-113M,Phosphonoformate immuno-associated protein 4,Proteasome regulatory particle subunit p44S10,p42A
26	NA (Z)	26S proteasome non-ATPase regulatory subunit 7	polymer	324	37086.4	1	UniProt (P51665)	Homo sapiens (human)	26S proteasome regulatory subunit RPN8,26S proteasome regulatory subunit S12,Mov34 protein homolog,Proteasome subunit p40
27	OA (W)	26S proteasome non-ATPase regulatory subunit 12	polymer	456	52979.4	1	UniProt (O00232)	Homo sapiens (human)	26S proteasome regulatory subunit RPN5,26S proteasome regulatory subunit p55
28	PA (A)	26S protease regulatory subunit 7	polymer	433	48700.8	1	UniProt (P35998)	Homo sapiens (human)	26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1
29	QA (B)	26S protease regulatory subunit 4	polymer	440	49260.5	1	UniProt (P62191)	Homo sapiens (human)	P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1
30	RA (C)	Isoform 2 of 26S proteasome regulatory subunit 8	polymer	398	44852.1	1	UniProt (P62195)	Homo sapiens (human)	26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG
31	SA (D)	26S protease regulatory subunit 6B	polymer	418	47426.1	1	UniProt (P43686)	Homo sapiens (human)	26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7
32	TA (E)	26S proteasome regulatory subunit 10B	polymer	403	45881.1	1	UniProt (A0A087X2I1)	Homo sapiens (human)
33	UA (F)	26S protease regulatory subunit 6A	polymer	439	49266.5	1	UniProt (P17980)	Homo sapiens (human)	26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1
34	VA (A)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
35	AB, WA, XA, YA, ZA (F, B, C, D, E)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	5	Chemie (ADP)

Sequence modifications

E: -13 - 389 (UniProt: A0A087X2I1)

PDB	External Database	Details
Ala 246	Gly 260	conflict

Contents of the asymmetric unit

Polymers	Number of chains	47
	Total formula weight	1691247.4
Non-Polymers*	Number of molecules	6
	Total formula weight	2643.2
All*	Total formula weight	1693890.5

*Water molecules are not included.