9SZP

Crystal structure of the human YTHDC2 YTH domain in complex with m6A DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	3'-5' RNA helicase YTHDC2	polymer	161	18684.0	1	UniProt (Q9H6S0)	Homo sapiens (human)	YTH domain-containing protein 2,hYTHDC2
2	B (B)	DNA (5'-D(*GP*GP*(6MA)P*CP*TP*A)-3')	polymer	6	1847.3	1		DNA molecule
3	C, D (A, B)	water	water		18.0	173	Chemie (HOH)

Sequence modifications

A: 1285 - 1424 (UniProt: Q9H6S0)

PDB	External Database	Details
Met 1264	-	initiating methionine
Gly 1265	-	expression tag
Ser 1266	-	expression tag
Ser 1267	-	expression tag
His 1268	-	expression tag
His 1269	-	expression tag
His 1270	-	expression tag
His 1271	-	expression tag
His 1272	-	expression tag
His 1273	-	expression tag
Ser 1274	-	expression tag
Gln 1275	-	expression tag
Asp 1276	-	expression tag
Pro 1277	-	expression tag
Glu 1278	-	expression tag
Asn 1279	-	expression tag
Leu 1280	-	expression tag
Tyr 1281	-	expression tag
Phe 1282	-	expression tag
Gln 1283	-	expression tag
Gly 1284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	20531.2
All*	Total formula weight	20531.2

*Water molecules are not included.