9SZ0
Crystal structure of PD-2016 bound METTL3-METTL14 complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N(6)-adenosine-methyltransferase catalytic subunit METTL3 | polymer | 225 | 25704.5 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N(6)-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 | polymer | 290 | 33691.3 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | ~{N}-[1-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]piperidin-4-yl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide | non-polymer | 473.6 | 1 | Chemie (A1JR7) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 357 - 580 (UniProt: Q86U44)
B: 111 - 399 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 356 | - | initiating methionine |
| Lys 568 | Arg 568 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 110 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59395.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 473.6 | |
| All* | Total formula weight | 59869.4 |
